Results 31 to 40 of about 7,818,543 (194)

DR5 is a restriction factor for human herpesviruses. [PDF]

Proc Natl Acad Sci U S A
Restriction factors are dominant proteins that target different essential steps of the viral life cycle; thus, these proteins provide an early line of defense against viruses. Here, we found that the internalization of DR5, an important receptor of the extrinsic apoptotic pathway, initiates apoptosis to inhibit Kaposi sarcoma–associated herpesvirus ...
Han C, Gui C, Su B, Liu N, Yan H, Lan K.
europepmc   +4 more sources

Dominant-Negative Proteins in Herpesviruses - From Assigning Gene Function to Intracellular Immunization [PDF]

, 2009
Investigating and assigning gene functions of herpesviruses is a process, which profits from consistent technical innovation. Cloning of bacterial artificial chromosomes encoding herpesvirus genomes permits nearly unlimited possibilities in the ...
Christian A. Mohr, Ulrich Koszinowski, Mühlbach, Hermine, Koszinowski, Ulrich H., Zsolt Ruzsics, Christian Mohr, Mohr, Christian A., Ruzsics, Zsolt, Hermine Mühlbach, Ulrich H. Koszinowski   +9 more
core   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors

Frontiers in Pharmacology, 2015
Human herpesviruses are widespread infectious pathogens that have been associated with proliferative and inflammatory diseases. During viral evolution, human herpesviruses have pirated genes encoding viral G protein-coupled receptors (vGPCRs), which are ...
Sabrina M de Munnik, Martine J Smit, Rob eLeurs, Henry F Vischer   +3 more
doaj   +1 more source

The Akt Forkhead Box O Transcription Factor Axis Regulates Human Cytomegalovirus Replication

mBio, 2022
The protein kinase Akt broadly impacts many cellular processes, including mRNA translation, metabolism, apoptosis, and stress responses. Inhibition of phosphatidylinositol 3-kinase (PI3K), a lipid kinase pivotal to Akt activation, triggers various ...
Hongbo Zhang, Anthony J. Domma, Felicia D. Goodrum, Nathaniel J. Moorman, Jeremy P. Kamil   +4 more
doaj   +1 more source

Animal models of tumorigenic herpesviruses—an update [PDF]

, 2015
Any one model system, be it culture or animal, only recapitulates one aspect of the viral life cycle in the human host. By providing recent examples of animal models for Epstein Barr Virus and Kaposi Sarcoma-associated Herpesvirus, we would argue that ...
Damania, Blossom, Dittmer, Dirk P, Sin, Sang-Hoon   +2 more
core   +1 more source

Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis

Nature Communications, 2020
Herpesviruses code for conserved protein kinases (CHPKs) that exert several regulatory functions by interacting with cellular factors. Here, the authors use affinity purification mass spectrometry (AP–MS) to identify differential interaction partners of ...
Boris Bogdanow, Max Schmidt, Henry Weisbach, Iris Gruska, Barbara Vetter, Koshi Imami, Eleonore Ostermann, Wolfram Brune, Matthias Selbach, Christian Hagemeier, Lüder Wiebusch   +10 more
doaj   +1 more source

Contribution of carbohydrate-related metabolism in Herpesvirus infections

Current Research in Microbial Sciences, 2023
Human herpesviruses are enveloped viruses with double-stranded linear DNA genomes highly prevalent in the human population. These viruses are subdivided into three subfamilies, namely alphaherpesvirinae (herpes simplex virus type 1, HSV-1; herpes simplex
Farías MA, Cancino FA, Navarro AJ, Soto AA, Pastén-Ferrada IA, Carreño LJ, González PA   +6 more
doaj   +1 more source

Evolution of human alpha-herpesviruses [PDF]

, 2007
Herpesviridae is a large virus family with more than 100 members, which are highly disseminated among animals. Three sub-families have been classified; alpha-herpesviruses, beta-herpesviruses and gamma-herpesviruses.
Norberg, Peter
core   +2 more sources

Herpesvirus infections of the central nervous system in immunocompromised patients

Therapeutic Advances in Neurological Disorders, 2012
Human herpesviruses may cause infections of the central nervous system during primary infection or following reactivation from a latent state. Especially in immunosuppressed patients the infection can take a life-threatening course, and therefore early ...
Uta Meyding-Lamadé, Cornelia Strank
doaj   +1 more source