Results 241 to 250 of about 388,090 (360)

Bispecific nanobody® as a new pharmacological drug for the selective inhibition of Trypsin‐3

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Proteolytic balance is dysregulated in many diseases, with proteases playing critical roles in pathological pathways. A high level of Trypsin‐3 expression has been implicated as a significant mediator of tumour progression and metastasis, and this protease is associated with poor prognosis for patients in various cancers.
Melissa David   +9 more
wiley   +1 more source

Missed and Delayed Diagnoses of Acute Human Immunodeficiency Virus (HIV) Infection in a Southern Opt-Out HIV Testing Environment Without Reflex HIV RNA Testing. [PDF]

open access: yesOpen Forum Infect Dis
Gruber SF   +8 more
europepmc   +1 more source

Organoid Models to Study Human Infectious Diseases

open access: yesCell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu   +4 more
wiley   +1 more source

Mechanotransduction Mediated by PDLIM5: The Critical Role of Serpin E2/Integrin β3‐Cytoskeleton‐Nucleoskeleton Axis in Mechanical Osteogenic Programming

open access: yesCell Proliferation, EarlyView.
Large segmental bone defects can result in non‐union of fractures and present a formidable challenge in clinical management. This study aims to investigate the role of mechanical stimulation in regulating osteogenic differentiation of stem cells via the mechanosensitive protein PDLIM5, thereby promoting bone regeneration and repair.
Yuchao Yang   +13 more
wiley   +1 more source

Combined screening of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus in an emergency department: The URDEPTRIO cross‐sectional study

open access: yes
Academic Emergency Medicine, EarlyView.
Chris Wong   +14 more
wiley   +1 more source

Vaccination in dermatology 2025: Update considering current recommendations of the German Standing Committee on Vaccination

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The immunosuppressive and immunomodulatory treatment of dermatological patients necessitates the regular review and updating of standard vaccinations and vaccines indicated for specific conditions. The German Standing Committee on Vaccination (STIKO) at the Robert Koch Institute regularly publishes evidence‐based vaccination recommendations ...
Johanna Stoevesandt   +3 more
wiley   +1 more source

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