Results 31 to 40 of about 681,627 (391)

Drug-Drug Interactions Among Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Medications [PDF]

, 2015
One-fourth of individuals diagnosed with the human immunodeficiency virus concomitantly have the hepatitis C virus infection. Since the discovery of highly active antiretroviral therapy, liver complications have become the leading cause of morbidity and ...
Gandhi, Mona A., Kaur, Kirpal, Slish, Judianne   +2 more
core   +2 more sources

Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease

Journal of Experimental Medicine, 1992
Human immunodeficiency virus (HIV) infection of brain macrophages and astroglial proliferation are central features of HIV-induced central nervous system (CNS) disorders. These observations suggest that glial cellular interactions participate in disease.
P. Genis, M. Jett, E. Bernton, T. Boyle, H. Gelbard, K. Dzenko, R. Keane, L. Resnick, Y. Mizrachi, D. Volsky, L. Epstein, H. Gendelman   +11 more
semanticscholar   +1 more source

Safety and practicality of an excisional lymph node study driving HIV cure research in South Africa

Frontiers in Immunology
IntroductionStudying diseased human tissues offers better insights into the intricate interactions between pathogens and the human host. In conditions such as HIV and cancers, where diseases primarily manifest in tissues, peripheral blood studies are ...
Trevor Khaba, Andrea Olga Papadopoulos, Thandeka Nkosi, Sifundo Nxele, Thandekile Ngubane, Ismail Jajbhay, Johan Pansegrouw, Zaza M. Ndhlovu, Zaza M. Ndhlovu, Zaza M. Ndhlovu   +9 more
doaj   +1 more source

Moderate restriction of macrophage-tropic human immunodeficiency virus type 1 by SAMHD1 in monocyte-derived macrophages.

PLoS ONE, 2014
Macrophage-tropic human immunodeficiency virus type 1 (HIV-1) strains are able to grow to high titers in human monocyte-derived macrophages. However, it was recently reported that cellular protein SAMHD1 restricts HIV-1 replication in human cells of the ...
Kahoru Taya, Emi E Nakayama, Tatsuo Shioda   +2 more
doaj   +1 more source

Estimating selection pressures on HIV-1 using phylogenetic likelihood models [PDF]

, 2008
Human immunodeficiency virus (HIV-1) can rapidly evolve due to selection pressures exerted by HIV-specific immune responses, antiviral agents, and to allow the virus to establish infection in different compartments in the body. Statistical models applied
Anisimova, Bailey, Embretson, Felsenstein, Goldman, Guindon, Ho, Huelsenbeck, Huelsenbeck, Kosakovsky Pond, Kosakovsky Pond, Kosakovsky Pond, Kosakovsky Pond, Kosakovsky Pond, Kosakovsky Pond, Kosakovsky Pond, Mansky, Massingham, Mayer-Hamblett, Muse, Nielsen, Novitsky, Pantaleo, Perelson, Perelson, Poon, Richman, Robinson, Rodrigue, Saitou, Schadt, Scheffler, Self, Seoighe, Shriner, Smith, Sugiura, Suzuki, Wei, Whelan, Whitley, Williamson, Yang, Yang, Yang, Yang, Yang, Zhuang   +47 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Development of a progressive HIV-1-Like infection model in northern pig-tailed macaques using stHIV-1sv/G53D

Emerging Microbes and Infections
Simian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV) infections in nonhuman primates closely approximate human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS), but intrinsic viral differences limit ...
Tian-Zhang Song, Qing Li, Li-Rong Zhang, Yan Hu, Ying Lu, Yong-Tang Zheng   +5 more
doaj   +1 more source

Identification of a novel retroviral gene unique to human immunodeficiency virus type 2 and simian immunodeficiency virus SIVMAC [PDF]

, 1988
Human and simian immunodeficiency-associated retroviruses are extraordinarily complex, containing at least five genes, tat, art, sor, R, and 3' orf, in addition to the structural genes gag, pol, and env.
Hahn, Beatrice H., Hood, Leroy E., Jameson, Bradford A., Kappes, John C., Kent, Stephen B. H., Lee, Shei-Wen, Morrow, Casey D., Shaw, George M.   +7 more
core  

Has HIV evolved to induce immune pathogenesis? [PDF]

, 2008
Human immunodeficiency virus (HIV) induces a chronic generalized activation of the immune system, which plays an important role in the pathogenesis of AIDS.
Bartha, István, Müller, Viktor, Simon, Péter   +2 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source