Results 81 to 90 of about 388,090 (360)

Approaches to repurposing reverse transcriptase antivirals in cancer

British Journal of Clinical Pharmacology, EarlyView.
This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head, Saiful Islam, Jennifer H. Martin   +2 more
wiley   +1 more source

Finding the Fit: A Review of Three Intervention Models for Working with HIV/AIDS Impacted Substance Users who are Homeless [PDF]

, 1999
This report reflects research on three different models of services for people living with Human Immunodeficiency Virus (HIV) or Acquired Immunodeficiency Syndrome (AIDS) who are also low-income, substance users and are homeless or at risk of becoming ...
Amy Rynell, Maryann Mason
core  

Annexin, a Protein for All Seasons: From Calcium Dependent Membrane Metabolism to RNA Recognition

BioEssays, EarlyView.
Annexins are an important protein family traditionally well known to bind to phospholipids and to interact with various proteins in a calcium dependent way. More recently, it has been established that a feature common to the family is also to bind to RNA having a role in translation. In bies70019 article, Vedeler et al.
Anni Vedeler, Gian Gaetano Tartaglia, Annalisa Pastore   +2 more
wiley   +1 more source

Structural Insights From HIV-Antibody Co-Evolution And Related Immunization Studies [PDF]

, 2018
Human immunodeficiency virus type 1 (HIV-1) is a rapidly evolving pathogen and causes the acquired immunodeficiency syndrome (AIDS) in humans. There are ~30-35 million people infected with HIV around the world, and ~25 million have died since the first ...
Fera, Daniela, Morriss, Julia W., , \u2719, Nguyen, Diep, , \u2719, Ton, Therese, , \u2719, Zhou, Jeffrey O., , \u2719   +4 more
core   +1 more source

Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants [PDF]

, 2014
Antibody-mediated immunotherapy is effective in humanized mice when combinations of broadly neutralizing antibodies (bNAbs) are used that target nonoverlapping sites on the human immunodeficiency virus type 1 (HIV-1) envelope.
Almond, Anna Gazumyan, Anthony P. West, Ariel Halper-Stromberg, Baenziger, Balazs, Barouch, Blish, Bosch, Bunnik, Burke, Cassie Liu, Clara Lehmann, Constance Williams, Doria-Rose, Florian Klein, Ganesh Phad, Gaufin, Gaufin, Gerd Fätkenheuer, Gunilla B. Karlsson Hedestam, Hioe, Horwitz, Huang, Jiang, Joshua A. Horwitz, Klein, Klein, Koch, Li, Lilian Nogueira, Ly, Malcolm A. Martin, Masashi Shingai, McCaffrey, McGuire, Michael S. Seaman, Michel C. Nussenzweig, Miller, Moldt, Mouquet, Mouquet, O’Rourke, Pamela J. Bjorkman, Pietzsch, Pietzsch, Pinter, Scheid, Scheid, Schmitz, Seaman, Shingai, Shingai, Simek, Sundling, Sundling, Sundling, Susan Zolla-Pazner, Thomas R. Eisenreich, Totrov, Walker, Walker, Wei, Yang, Yoshiaki Nishimura, Zhang, Zolla-Pazner, Zolla-Pazner   +67 more
core   +1 more source

Human immunodeficiency virus prevention and testing strategies among men who have sex with men in the UK: the PANTHEON research programme including the SELPHI RCT

Programme Grants for Applied Research
Background Rates of human immunodeficiency virus diagnoses in UnitedKingdom men who have sex with men were at a 10-year high in 2014; many recent infections indicated ongoing transmission. There was a need to increase testing rates, reduce late diagnosis
Janey Sewell, T Charles Witzel, David Dunn, Fiona Lampe, Fiona Burns, Peter Weatherburn, Sheena McCormack, Leanne McCabe, Alec Miners, Valentina Cambiano, Roger Pebody, Roy Trevelion, Nadia Hanum, Andrew Phillips, Alison Rodger   +14 more
doaj   +1 more source

HIV-1 Vaccine Development: studies in Macaque models [PDF]

, 1997
Since its discovery about 15 years ago, human immunodeficiency virus type 1 (HtV-1) continues·to spread at an alarming rate. It is estimated that by the year 2000 between 30 and 40 million people will be infected with this virus worldwide'.
Hulskotte, E.G.J. (Ellen)
core   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source

The Human Immunodeficiency Virus - a Review of the clinical aspects and detection of the infection

Quality in Sport
Introduction: Currently, many people are infected with the human immunodeficiency virus (HIV). Transmission is primarily through sexual contact, with additional routes including mother-infant exposure to needles and needle sharing.
Martyna Choinka, Agata Konopka, Natalia Wdowiak, Zuzanna Szczepaniak, Jakub Kalisiak, Anna Szpernalowska, Vimbisoyashe Ivy Matshaba, Karolina Mrugała   +7 more
doaj   +1 more source

Designing Cyclic Nitrogen‐Bridged Sulfonamides with Anti‐Cancer Activity

ChemMedChem, EarlyView.
Nitrogen bridgehead compounds, especially cyclic sulfonamides, are an abundant motif in bioactive compounds. simple methods for the synthesis of nitrogen bridgehead sulfonamides is developed and their activity against cancer cell lines is explored. The N‐bridgehead heterocyclic structure is an abundant motif in a multitude of natural products.
Benedikt W. Grau, Arpit Dheeraj, Irimpan I. Mathews, Dhanir Tailor, Sanjay V. Malhotra   +4 more
wiley   +1 more source