Results 61 to 70 of about 1,886,374 (299)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A mobile handshake robot system for generation of handshake request motion during active approach to a human

Nihon Kikai Gakkai ronbunshu, 2015
Humans shake hands as a sign of greeting when they first meet, to greet one another and develop a rapport. A handshake is an embodied interaction through physical contact.
Shunsuke OTA, Mitsuru JINDAI, Hitoshi YAMAUCHI, Tomio WATANABE   +3 more
doaj   +1 more source

Human-entrained embodied interaction and communication technology for human-connected IoT design

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2020
In human face-to-face conversation, embodied rhythms between speech and body motions such as nodding are mutually synchronized not only between talkers but also in a talker.
Tomio WATANABE
doaj   +1 more source

Human Machine Interface [PDF]

Journal of Electrical & Electronic Systems, 2016
An industrial control user interface N€rоvN–dеN• а flexible, extensible architecture fоr thе provision оf real-time process data tо а state-of-the-art user interface, uN•N–ng MSHTML аN• thе underlying rendering engine. Thе architecture оf thе interface N€rоvN–dеN• а user interface thаt N–N• designed tо harness key industry standard ...
openaire   +1 more source

Human Rights and Intellectual Property: Mapping the Global Interface [PDF]

, 2010
Human Rights and Intellectual Property: Mapping the Global Interface explores the intersections between intellectual property and human rights law and policy.
Austin, Graeme W., Helfer, Laurence R.
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences [PDF]

, 2014
Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based ‘click’ ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric ...
Alex R. O. Cousins, Balkwill, Bejugam, Biffi, Brooks, De Armond, De Cian, Dougal Ritson, Feng, Fernando, Fletcher, Garner, Grand, Haider, Huppert, John E. Moses, Kim, Kumari, Lingner, Lipps, Malcolm F. G. Stevens, Mark S. Searle, Mergny, Moorhouse, Moorhouse, Nakamura, Neidle, Pallavi Sharma, Petraccone, Petraccone, Randall, Renciuk, Ritson, Searle, Siddiqui-Jain, Todd, Vorlickova, Wang, Xu   +38 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Presentation Capability of Compound Displays for Pressure and Force

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2008
The authors developed advanced haptic displays capable of stimulating the muscles and tendons of the forearms and tactile receptors in fingers to investigate tactile and force effects on simultaneous presentation.
Masahiro OHKA, Keitaro KATO, Takehiro FUJIWARA, Yasunaga MITSUYA, Tetsu MIYAOKA   +4 more
doaj   +1 more source