Results 61 to 70 of about 1,891,996 (295)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Nodding detection system based on head motion and voice rhythm

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2021
Human beings communicate using more than verbal communication. To communicate smoothly, humans tend to use nonverbal information such as nodding during embodied interactions.
Shunsuke OTA, Seiko TAKI, Mitsuru JINDAI, Toshiyuki YASUDA   +3 more
doaj   +1 more source

A Framework for Mouse Emulation that Uses a Minimally Invasive Tongue Palate Control Device utilizing Resistopalatography [PDF]

, 2013
The ability to interface fluently with a robust Human Input Device is a major challenge facing patients with severe levels of disability. This paper describes a new method of computer interaction utilizing Force Sensitive Resistor Array Technology ...
Horne, Robert, Kelly, Stephen W., Lee, Peter   +2 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Quantitative analysis of bone reactions to relative motions at implant-bone interfaces [PDF]

, 1993
Connective soft tissues at the interface between implants and bone, such as in human joint replacements, can endanger the stability of the implant fixation. The potential of an implant to generate interface bone resorption and form soft tissue depends on
Brunski, Brunski, Carey, Carter, Cowin, Draenert, Eftekar, Feith, Goldring, Gruen, H Weinans, H.J Grootenboer, Harris, Hori, Hori, Huiskes, Huiskes, Huiskes, Huiskes, Kozinn, Krause, Kölbel, Lewis, Ling, Pauwels, Perren, Perren, Pizzoferrato, R Huiskes, Santare, Schneider, Spector, Stauffer, Stone, Strens, Søballe, Søballe, Uhthoff, Vanderby, Walker, Weinans, Willert   +41 more
core   +4 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Emission Characteristics of Odorous Compounds from a Swine Farm on Jeju Island, Korea

Atmosphere
This study investigated 26 malodorous substances emitted from a swine farm on Jeju Island, South Korea, to discern their specific emission characteristics and potential implications for workers’ health and environmental management. A detailed analysis of
Jung-Min Song
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences [PDF]

, 2014
Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based ‘click’ ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric ...
Alex R. O. Cousins, Balkwill, Bejugam, Biffi, Brooks, De Armond, De Cian, Dougal Ritson, Feng, Fernando, Fletcher, Garner, Grand, Haider, Huppert, John E. Moses, Kim, Kumari, Lingner, Lipps, Malcolm F. G. Stevens, Mark S. Searle, Mergny, Moorhouse, Moorhouse, Nakamura, Neidle, Pallavi Sharma, Petraccone, Petraccone, Randall, Renciuk, Ritson, Searle, Siddiqui-Jain, Todd, Vorlickova, Wang, Xu   +38 more
core   +1 more source