Results 241 to 250 of about 401,671 (363)

Circulating donor-specific cytotoxic T lymphocytes with high avidity for donor human leukocyte antigens in pediatric and adult cardiac allograft valved conduit recipients✩ [PDF]

, 2000
Frans B S Oei, Marij J.P. Welters, Christiaan J. Knoop, L. M. B. Vaessen, Alexander P.A. Stegmann, Willem Weimar, Ad J.J.C. Bogers   +6 more
openalex   +1 more source

CDK4/6 Inhibitor Priming Enhances PD‐1 Blockade via Sellhi Neutrophil‐Induced Stat5a+ Progenitor Exhausted CD8+ T Cell

Advanced Science, EarlyView.
Activated tumor‐intrinsic cyclin D1‐CDK4/6 signaling attenuates lymphocyte infiltration, and consequently, and immunotherapy resistance in HNSCC. It is discovered that brief CDK4/6i priming before anti‐PD‐1 results in enhanced durability of ICB response durability through Stat5a+ progenitor exhausted CD8+ T cells induced by IL15‐secreted Sell(hi ...
Yu Zhang, Bao Sun, Rong Zhou, Zizhen Gong, Yong Han, Wenjie Tao, Chaoji Shi, Wuchang Zhang, Laikui Liu, Zhiyuan Zhang, Jiang Li, Qi Zhu, Weiwen Zhu, Ziyue Gu   +13 more
wiley   +1 more source

Clinical settings in which human leukocyte antigen typing is still useful in the diagnosis of celiac disease. [PDF]

World J Gastroenterol
Schirru E, Rossino R, Jores RD, Corpino M, Muntoni S, Cucca F, Congia M.   +6 more
europepmc   +1 more source

β-Cell Autoantibodies, Human Leukocyte Antigen II Alleles, and Type 1 Diabetes in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy* [PDF]

, 2000
M Gylling, Jaakko Tuomilehto, Petra Björses, S Kontiainen, Jukka Partanen, Michael R. Christie, Mikael Knip, Jaakko Perheentupa, Aaro Miettinen   +8 more
openalex   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Human Leukocyte Antigen-DR Expression on Monocytes Is a Useful Predictor in a Systemic Inflammation Response-Based Prognostic Model in Advanced Non-Small Cell Lung Cancer. [PDF]

Int J Mol Sci
Szűcs G, Gézsi A, Szentkereszty M, Losonczy G, Barna G, Gálffy G, Bohács A, Tamási L, Müller V, Buzás EI, Komlósi ZI.   +10 more
europepmc   +1 more source

Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment

Advanced Science, EarlyView.
Molybdenum (Mo), with its unique strength, uniform corrosion, and radiopacity, enables innovative biodegradable implants for transformative stroke therapy. Abstract Neurovascular implants for stroke intervention face a critical dilemma: permanent devices (e.g., nitinol stents, platinum coils) often trigger chronic inflammation and recurrence, whereas ...
Yunong Shen, Yiming Huang, Yang Zhang, Chunhao Yu, Hanqi Liu, Dong Bian, Di Wu, Wu Wang, Xunming Ji, Yufeng Zheng, Miaowen Jiang, Ming Li   +11 more
wiley   +1 more source

Synergistic Anti‐Cancer Therapy Through Ultrasound‐Induced Piezocatalytic Therapy and Tumor Treatment Fields

Advanced Science, EarlyView.
A novel, wearable anti‐cancer platform synergistically combines tumor treating fields (TTFs) and piezocatalytic therapy (PCT) via ultrasound‐activated, lead‐free piezocomposites. This strategy efficiently suppresses tumor growth, modulates the immune microenvironment, and demonstrates strong therapeutic synergy in both mouse model of subcutaneous tumor
Jing Jin, Haoyue Xue, Keliang Chen, Yonglin Su, Xin Hu, Xiaolin Hu, Xing Huang, Laiming Jiang, Jiagang Wu, Xingchen Peng   +9 more
wiley   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity

Advanced Science, EarlyView.
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley   +1 more source