Results 51 to 60 of about 359,068 (363)
Tumor-reactive immune cells protect against metastatic tumor and induce immunoediting of indolent but not quiescent tumor cells [PDF]
, 2016 Two major barriers to cancer immunotherapy include tumor-induced immune suppression mediated by myeloid-derived suppressor cells and poor immunogenicity of the tumor-expressing self-antigens.
Bear, Harry D. +8 more
core +2 more sources
Analysis of Human Leukocyte Antigen Frequency among Renal Transplant Recipients and Donors in Nepal
Global Journal of Transfusion MedicineBackground and Objectives: Kidney transplants are effective for advanced renal failure, but graft rejection can occur when the recipient’s immune system misidentifies the kidney as a foreign object.
Rekha Manandhar +3 more
doaj +1 more source
Tzu-Chi Medical Journal, 2019 Objective: Human leukocyte antigen (HLA)-DRB1*15:140 is a low-frequency allele in the HLA-DRB1 locus. The aim of this study is to confirm the ethnicity of DRB1*15:140 and to deduce a probable HLA-DRB1*15:140-associated HLA haplotype in Taiwanese ...
Kuo-Liang Yang, Zheng-Zhong Zheng
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Chimerism and xenotransplantation: New concepts [PDF]
, 1999 In both transplant and infectious circumstances, the immune response is governed by migration and localization of the antigen. If the antigenic epitopes of transgenic xenografts are sufficiently altered to avoid evoking the destructive force of innate ...
Demetris, AJ +5 more
core +1 more source
Tzu Chi Medical Journal, 2017 Objective: Human leukocyte antigen (HLA) DRB1*04:36 is a low-frequency HLA-DRB1 allele. The aim here is to report the ethnicity of DRB1*04:36 and its associated HLA haplotypes among Taiwanese individuals.
Kuo-Liang Yang, Zheng-Zhong Zheng
doaj +1 more source
Sarcopenia and Variation in the Human Leukocyte Antigen Complex [PDF]
The Journals of Gerontology: Series A, 2019 Abstract Background Aging is characterized by chronic inflammation plus loss of muscle mass and strength, termed sarcopenia. Human leukocyte antigen (HLA) types are drivers of autoimmune disease, although with limited penetrance.
David Melzer +6 more
openaire +4 more sources
Quantifying the impact of Human Leukocyte Antigen on the human gut microbiome [PDF]
mSphere, 2020 AbstractObjectiveThe gut microbiome is affected by a number of factors, including the innate and adaptive immune system. The major histocompatibility complex (MHC), or the human leukocyte antigen (HLA) in humans, performs an essential role in vertebrate immunity, and is very polymorphic in different populations.
Andeweg, Stijn P. +2 more
openaire +7 more sources
Molecular Oncology, EarlyView.Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink +6 more
wiley +1 more source
A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. [PDF]
, 1993 Using an in vivo test system, the role of the β1 integrin very late activation antigen-4 (VLA-4) in eosinophil accumulation in allergic and nonallergic inflammatory reactions was investigated.
Lobb, RR +3 more
core +1 more source