Results 131 to 140 of about 8,960,514 (293)

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries

, 2009
Present drug screening libraries are constrained by biophysical properties that predict desirable pharmacokinetics and structural descriptors of 'drug-likeness' or 'lead-likeness'.
Dobson, Paul D., Patel, Yogendra, Kell, Douglas B.   +2 more
core   +1 more source

Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires. [PDF]

MAbs, 2020
Schmitz S, Soto C, Crowe JE, Meiler J.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Haptic human-robot collaboration: Comparison of robot partner implementations in terms of human-likeness and task performance

, 2011
In the past, working spaces of humans and robots were strictly separated, but recent developments have sought to bring robots into closer interaction with humans.
Groten, Raphaela, Buss, Martin, Daniela Feth, Feth, Daniela, Peer, Angelika   +4 more
core   +1 more source

The effects of human-like social cues on social responses towards text-based conversational agents—a meta-analysis

Humanities & Social Sciences Communications
Humanizing chatbots through social cues is a common strategy to increase user acceptance. However, whether and in which circumstances this strategy is generally effective is still unclear.
Stefanie Helene Klein
doaj   +1 more source

Deviation from typical organic voices best explains a vocal uncanny valley

Computers in Human Behavior Reports
The uncanny valley describes the negative evaluation of near humanlike artificial entities. Previous research with synthetic and real voices failed to find an uncanny valley of voices. This may have been due to an incomplete selection of stimuli.
Alexander Diel, Michael Lewis
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Adoption in human-like AI system: A moderated-mediation approach

Journal of Open Innovation: Technology, Market and Complexity
Human-like AI systems increasingly interact with users as partners, but it is still unclear how perceived human-likeness leads to adoption and when transparency helps or dilutes that effect.
Vu Minh Ngo, Hang Thuy Thi Le, Ngoc Thuy Vuong   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source