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Impact of Gold Nanoparticles on Testosterone Metabolism in Human Liver Microsomes. [PDF]
Nanoscale Res Lett, 2019 Choi K, Joo H.
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OXIDATIVE DRUG METABOLISM IN HUMAN LIVER MICROSOMES
The Journal of Pharmacology and Experimental Therapeutics, 1971Isolated human liver microsomes were studied with respect to reduced nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome c reductase, NADPH-cytochrome P-450 reductase, aminopynine demethylase activity and the content of cytochrome P-450 ...
E B, Nelson +3 more
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Tolbutamide hydroxylation by human liver microsomes
Biochemical Pharmacology, 1988John O. Miners +5 more
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Journal of Pharmacology and Experimental Therapeutics, 1994
Interindividual variations in the level and activity of cytochrome P-450 enzymes were investigated in the liver microsomes of 30 Japanese and 30 Caucasian patients.
T. Shimada +4 more
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Interindividual variations in the level and activity of cytochrome P-450 enzymes were investigated in the liver microsomes of 30 Japanese and 30 Caucasian patients.
T. Shimada +4 more
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The lipid composition of human liver microsomes
Lipids, 1982AbstractThe lipid composition of human liver microsomes isolated from liver biopsy samples obtained at abdominal surgery has been determined. Human liver microsomal phospholipid is composed of 49% phosphatidylcholine, 31% phosphatidylethanolamine, 14% phosphatidylserine+phosphatidylinositol and 6% sphingomyelin, very similar to the phospholipid ...
L, Waskell, D, Koblin, E, Canova-Davis
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Biotransformation of (−)-Verbenone by Human Liver Microsomes
Bioscience, Biotechnology, and Biochemistry, 2002The biotransformation of (-)-verbenone was investigated with human liver microsomes by using GC-MS. Regioselective biotransformation was observed when (-)-verbenone was incubated with the liver microsomes. (-)-10-Hydroxyverbenone was formed from (-)-verbenone of kinetic analysis showed that the Km and Vmax values for the hydroxylation of (-)-verbenone ...
Mitsuo, Miyazawa +2 more
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Phenobarbital N-glucosylation by human liver microsomes
European Journal of Drug Metabolism and Pharmacokinetics, 2004Glucosylation of xenobiotics in mammals has been observed for a limited number of drugs. Generally, these glucoside conjugates are detected as urinary excretion products with limited information on their formation. An in vitro assay is described for measuring the formation of the phenobarbital N-glucoside diasteriomers ((5R)-PBG, (5S)-PBG) using human ...
Sheela G, Paibir +3 more
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Drug Metabolism And Disposition, 1995
Identifying selective inhibitors of cytochrome P450 isoforms is a useful tool in defining the role of individual cytochrome P450s in the metabolism process.
D. Newton, R. Wang, A. Y. Lu
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Identifying selective inhibitors of cytochrome P450 isoforms is a useful tool in defining the role of individual cytochrome P450s in the metabolism process.
D. Newton, R. Wang, A. Y. Lu
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Microsomal Esterification of Retinol in Human Liver
Acta Medica Scandinavica, 1984Abstract Recent work has shown that esterification of retinol in microsomes from rat liver, mammary gland and small intestine and from human small intestine is catalyzed by an acyl CoA: retinol acyl transferase (ARAT). The current study demonstrates ARAT activity in human liver microsomes.
M, Rasmussen +3 more
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