Results 171 to 180 of about 2,261,504 (355)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation

Nature Communications
T cell activation requires extensive metabolic reprogramming, but the specific requirement for mitochondrial respiration (MR) remains unresolved. While most studies have focused on aerobic glycolysis as the primary driver of proliferation and effector ...
Tatiana N. Tarasenko, Emily Warren, Bharati Singh, Amanda Fuchs, Jose Marin, Marten Szibor, Christopher King, Peter J. McGuire   +7 more
doaj   +1 more source

Polyphenols-Ensured Accessibility from Food to the Human Metabolism by Chemical and Biotechnological Treatments. [PDF]

Antioxidants (Basel), 2023
Pop OL, Suharoschi R, Socaci SA, Berger Ceresino E, Weber A, Gruber-Traub C, Vodnar DC, Fărcaș AC, Johansson E.   +8 more
europepmc   +1 more source

Human norepinephrine metabolism [PDF]

Journal of Clinical Investigation, 1971
Stanley E. Gitlow, Milton Mendlowitz, Laura M. Bertani, Sherwin Wilk, Elizabeth K. Wilk   +4 more
openaire   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte‐based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I) [PDF]

, 2012
Christine Götz, Roland Pfeiffer, Julia Tigges, Veronika Blatz, Christine Jäckh, Eva‐Maria Freytag, Eric Fabian, Robert Landsiedel, Hans F. Merk, Jean Krutmann, Robert J. Edwards, Camilla Pease, Carsten Goebel, Nicola J. Hewitt, Ellen Fritsche   +14 more
openalex   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Editorial: The role of cofactors in protein stability and homeostasis: Focus on human metabolism. [PDF]

Front Mol Biosci, 2023
Marchetti M, Puglisi R, Cellini B, Dindo M, Marchesani F.   +4 more
europepmc   +1 more source

Transport and Metabolism of Serotonin in the Human Placenta from Normal and Severely Pre-Eclamptic Pregnancies

, 2000
Gonzalo A. Carrasco, Marı́a Antonieta Cruz, Victoria Gallardo, P. Miguel, Alejandra Domínguez, Clemente González   +5 more
openalex   +2 more sources

STUDIES OF THE METABOLISM OF HUMAN SPERMATOZOA [PDF]

, 1968
R. N. Murdoch, I. G. White
openalex   +1 more source