Results 191 to 200 of about 1,287,033 (265)

In Vitro and In Vivo Human Metabolism of Ostarine, a Selective Androgen Receptor Modulator and Doping Agent. [PDF]

Int J Mol Sci
Taoussi O, Bambagiotti G, Gameli PS, Daziani G, Tavoletta F, Tini A, Basile G, Lo Faro AF, Carlier J.   +8 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Short-term changes in human metabolism following a 5-h delay of the light-dark and behavioral cycle. [PDF]

iScience
Flanagan A, Ruddick-Collins LC, Fielding B, Middleton B, von Gerichten J, Short M, Revell V, Mendis J, Mayer CD, Morgan PJ, Johnstone AM, Johnston JD.   +11 more
europepmc   +1 more source

Analysis of human metabolism by reducing the complexity of the genome-scale models using redHUMAN. [PDF]

Nat Commun, 2020
Masid M, Ataman M, Hatzimanikatis V.
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Human Metabolism [PDF]

Nature, 1920
openaire   +1 more source

Human metabolism of the semi-synthetic cannabinoids hexahydrocannabinol, hexahydrocannabiphorol and their acetates using hepatocytes and urine samples. [PDF]

Drug Test Anal
Lindbom K, Norman C, Baginski S, Krebs L, Stalberga D, Rautio T, Wu X, Kronstrand R, Gréen H.   +8 more
europepmc   +1 more source

Commentary: Dietary methionine influences therapy in mouse cancer models and alters human metabolism. [PDF]

Front Oncol, 2020
Abid MA, Abid MB.
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Human metabolism of four synthetic benzimidazole opioids: isotonitazene, metonitazene, etodesnitazene, and metodesnitazene. [PDF]

Arch Toxicol
Taoussi O, Berardinelli D, Zaami S, Tavoletta F, Basile G, Kronstrand R, Auwärter V, Busardò FP, Carlier J.   +8 more
europepmc   +1 more source