Results 201 to 210 of about 1,389,274 (311)

Human metabolism and urinary excretion of seven neonicotinoids and neonicotinoid-like compounds after controlled oral dosages. [PDF]

Arch Toxicol, 2022
Wrobel SA, Bury D, Hayen H, Koch HM, Brüning T, Käfferlein HU.   +5 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Nutritional, pharmacological and hormonal manipulation of muscle metabolism

, 2010
PhDSarcopenia and cachexia occur when there is a deficit between the rates of muscle protein synthesis and breakdown, such that a negative balance exists.
Wilkes, Emilie Anne
core  

Artificial intelligence and computational methods in human metabolism research: A comprehensive survey. [PDF]

J Pharm Anal
Zhang M, Wan Y, Wang J, Li S, Li H.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Stereoselective metabolism by human liver CYP enzymes of a substituted benzimidazole

, 2000
H 259/31 is a substituted benzimidazole developed as a structural analog of omeprazole. Metabolites of H 259/31 formed in human liver microsomes were identified by using the synthetic reference compounds and liquid chromatography/mass spectrometry.
Weidolf, L, Abelö, A, Andersson, TB, Bredberg, U, Skånberg, I   +4 more
core  

5-Methyl etodesnitazene human metabolism: LC-ESI^±-HRMS/MS analysis (mono- and di-protonation) of human hepatocyte incubations and positive biospecimens. [PDF]

Anal Bioanal Chem
Taoussi O, Carlier J, Gameli PS, Huppertz LM, Bambagiotti G, Tavoletta F, Tini A, Berardinelli D, Busardò FP, Auwärter V.   +9 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Bioavailability, Human Metabolism, and Dietary Interventions of Glucosinolates and Isothiocyanates: Critical Insights and Future Perspectives. [PDF]

Foods
Narra F, Galgani G, Harris CB, Moreno DA, Núñez-Gómez V.   +4 more
europepmc   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source