Results 211 to 220 of about 1,389,274 (311)

Essential Trace Elements in the Human Metabolism. [PDF]

Biology (Basel)
da Silva JAL.
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

MXene/Carboxymethyl Chitosan Moisture Responsive Soft Actuator with Diode-Like Actuation for Versatile Applications Driven by Human Metabolism. [PDF]

Adv Sci (Weinh)
Xu L, Ling Y, Li Z, Xu X, Li X, Chang L, Peng Q, Hu Y.   +7 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Bioactive Peptides in Greek Goat Colostrum: Relevance to Human Metabolism. [PDF]

Foods
Petre ML, Kontouli Pertesi AN, Boulioglou OE, Sarantidi E, Korovesi AG, Kozei A, Katsafadou AI, Tsangaris GT, Trichopoulou A, Anagnostopoulos AK.   +9 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Human metabolism and pharmacological profiling of protonitazepyne and metonitazepyne, two highly potent nitazenes: prediction of main metabolite activity based on µ-opioid receptor docking simulations. [PDF]

Arch Toxicol
Berardinelli D, Taoussi O, Ovat DY, Pichini S, Pulver B, Auwärter V, Busardò FP, Basile G, Laudadio E, Carlier J.   +9 more
europepmc   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Dipyanone, a new methadone-like synthetic opioid: In vitro and in vivo human metabolism and pharmacological profiling. [PDF]

Arch Toxicol
Berardinelli D, Kutzler J, Taoussi O, Zaami S, Pichini S, Basile G, Busardò FP, Auwärter V, Carlier J.   +8 more
europepmc   +1 more source

In vitro and in vivo human metabolism and pharmacokinetics of S- and R-praziquantel. [PDF]

Pharmacol Res Perspect, 2020
Kapungu NN, Li X, Nhachi C, Masimirembwa C, Thelingwani RS.   +4 more
europepmc   +1 more source