Results 171 to 180 of about 1,287,033 (265)

Essential Trace Elements in the Human Metabolism. [PDF]

Biology (Basel)
da Silva JAL.
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

MXene/Carboxymethyl Chitosan Moisture Responsive Soft Actuator with Diode-Like Actuation for Versatile Applications Driven by Human Metabolism. [PDF]

Adv Sci (Weinh)
Xu L, Ling Y, Li Z, Xu X, Li X, Chang L, Peng Q, Hu Y.   +7 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Bioactive Peptides in Greek Goat Colostrum: Relevance to Human Metabolism. [PDF]

Foods
Petre ML, Kontouli Pertesi AN, Boulioglou OE, Sarantidi E, Korovesi AG, Kozei A, Katsafadou AI, Tsangaris GT, Trichopoulou A, Anagnostopoulos AK.   +9 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Human metabolism and pharmacological profiling of protonitazepyne and metonitazepyne, two highly potent nitazenes: prediction of main metabolite activity based on µ-opioid receptor docking simulations. [PDF]

Arch Toxicol
Berardinelli D, Taoussi O, Ovat DY, Pichini S, Pulver B, Auwärter V, Busardò FP, Basile G, Laudadio E, Carlier J.   +9 more
europepmc   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Dipyanone, a new methadone-like synthetic opioid: In vitro and in vivo human metabolism and pharmacological profiling. [PDF]

Arch Toxicol
Berardinelli D, Kutzler J, Taoussi O, Zaami S, Pichini S, Basile G, Busardò FP, Auwärter V, Carlier J.   +8 more
europepmc   +1 more source

In vitro and in vivo human metabolism and pharmacokinetics of S- and R-praziquantel. [PDF]

Pharmacol Res Perspect, 2020
Kapungu NN, Li X, Nhachi C, Masimirembwa C, Thelingwani RS.   +4 more
europepmc   +1 more source