Results 221 to 230 of about 1,240,536 (340)

The ferroform and glycoform landscape of human milk lactoferrin dissected through hybrid mass spectrometric approaches. [PDF]

open access: yesFront Nutr
Zhu J   +7 more
europepmc   +1 more source

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems

open access: yesAdvanced Science, EarlyView.
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo   +18 more
wiley   +1 more source

Human milk-derived 5'-UMP promotes thermogenesis and mitochondrial biogenesis to ameliorate obesity. [PDF]

open access: yesFront Nutr
Zhang L   +8 more
europepmc   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

open access: yesAdvanced Science, EarlyView.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu   +20 more
wiley   +1 more source

Seal milk oligosaccharides rival human milk complexity and exhibit functional dynamics during lactation. [PDF]

open access: yesNat Commun
Jin C   +11 more
europepmc   +1 more source

Chemoenzymatic Synthesis of a Library of Human Milk Oligosaccharides

open access: green, 2016
Zhongying Xiao   +13 more
openalex   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

open access: yesAdvanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu   +13 more
wiley   +1 more source

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