Results 51 to 60 of about 2,550,064 (264)

Solidarity and Human Nature

, 2021
The concept of solidarity inhabits the collective unconscious and is usually related to something consensual, linked to the most basic values of mankind, but to expand that understanding leads to more complex views. Human solidarity would be conditioned by biological, or cultural issue that goes beyond any possible biological determinism.
Luis Miguel dos Santos Luzio, Bernardo Carlos Spaulonci Chiachia Matos de Oliveira   +1 more
openaire   +2 more sources

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Human Nature in Ancient Philosophy and its Influence On Modern Philosophy

Kalagatos
The concept of "human nature" is analyzed from the perspective of classical philosophy, with a focus on the thought of Mencius, a great Confucian philosopher.
Nguyen Thi Thu, Nguyen Van Thanh, Nguyen Minh Hoan   +2 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Anarchist-Socialist Praxis and Embodied Human Nature

Eidos. A Journal for Philosophy of Culture
The idea of human nature can be wielded to justify exploitation and domination, but drawing on the work of Noam Chomsky, Murray Bookchin and others, I argue consideration of our embodied nature can help humans thrive.
James Anderson
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Modeling roles and trade-offs in multiplex networks

Nature Communications
Multiplex social networks capture multiple types of relations among the same people. Their structure reflects how exchanges arise from individual attributes related to independence, the status or resources of others related to dependence, and mutual ...
Nikolaos Nakis, Sune Lehmann, Nicholas A. Christakis, Morten Mørup   +3 more
doaj   +1 more source

EXPLAINING AND VALUING: AN EXCHANGE BETWEEN THEOLOGY AND THE HUMAN SCIENCES

Zygon, 1995
. A comparison of E.O. Wilson's On Human Nature and Abraham Heschel's Who Is Man? introduces a discussion of how descriptions and explanations of the human are related to valuations of the human.
doaj   +2 more sources