Results 51 to 60 of about 14,023,849 (296)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Dynamics of sulfate and nitrate in a temperate stream network: combining multi-isotope analysis and generalized linear mixed-effects models for precautionary conservation

Progress in Earth and Planetary Science
Environmental pollution in stream networks is a major concern. In this study, the effects of land-use and geological characteristics on basin-scale sulfate and nitrate dynamics in the Chikusa River basin, Hyogo, Japan, where substantial environmental ...
Lei Fujiyoshi, Ichiro Tayasu, Shiho Yabusaki, Takashi F. Haraguchi, Chikage Yoshimizu, Ken’ichi Ohkushi, Fumiko Furukawa, Masayuki Itoh, Tadashi Yokoyama, Hiromune Mitsuhashi   +9 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Attentional bias towards smartphone stimuli is associated with decreased interoceptive awareness and increased physiological reactivity

Communications Psychology
Excessive smartphone use has been linked to negative psychological outcomes and may also be associated with cognitive impairments and disruptions in mind-body interaction, though the underlying mechanisms remain unclear. Here, we investigated attentional
Yusuke Haruki, Katsunori Miyahara, Kenji Ogawa, Keisuke Suzuki   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Early Cretaceous troodontine troodontid (Dinosauria: Theropoda) from the Ohyamashimo Formation of Japan reveals the early evolution of Troodontinae

Scientific Reports
A new troodontid dinosaur, Hypnovenator matsubaraetoheorum gen. et sp. nov., is described based on an articulated postcranial skeleton recovered from the fluvial deposits of the Albian Ohyamashimo Formation of the Sasayama Group in Tambasasayama City ...
Katsuhiro Kubota, Yoshitsugu Kobayashi, Tadahiro Ikeda   +2 more
doaj   +1 more source

Political realism, Freud, and human nature in international relations [PDF]

, 2009
Political realism has enjoyed a renaissance in International Relations (IR). Recent studies have provided insightful accounts of its timeless virtues and philosophical depth.
Schütt, Robert, Schuett, R
core  

Enhancement and Human Nature: The Case of Sandel

, 2009
If we assume that "enhancement" names all efforts to boost human mental and physical capacities beyond the normal upper range found in our species, then enhancement covers such a broad range of interventions that it becomes implausible to think that ...
Lewens, T.
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Intentional binding reflects pair dynamics and sense of agency in embodied joint action in human-human dyads but not in human-computer dyads

Frontiers in Psychology
Intentional binding has been proposed as an implicit measure of shared sense of agency in joint action, yet it remains unclear whether it distinguishes between individual and different forms of joint control.
Felix Woolford, Keisuke Suzuki
doaj   +1 more source