Results 61 to 70 of about 8,092,812 (313)
Book Review: The Perfectability of Human Nature in Eastern and Western Thought [PDF]
, 2009 A review of The Perfectability of Human Nature in Eastern and Western Thought by Harold ...
Malkovsky, Bradley
core +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A Master Wittgensteinian Surveys Human Nature -A Review of Human Nature-the Categorial Framework by PMS Hacker (2010) (review revised 2019) [PDF]
, 2019 Materialism, reductionism, behaviorism, functionalism, dynamic systems theory and computationalism are popular views, but they were shown by Wittgenstein and more recently by Searle to be incoherent.
Starks, Michael
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Religion and the Mystery of Existence [PDF]
, 2012 This paper questions the idea that theism can function as an explanatory hypothesis to account for the nature and origins of the cosmos. Invoking God cannot dissolve the mystery of existence, and the characteristic religious response here is one of awe ...
Cottingham, John
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Meaning of Concepts of Human Nature in Organizational Life in Business Ethics Context [PDF]
, 2014 The main goal of this paper is to exhibit the role of the concept of human nature for the ethical orientation of organizational life. Therefore, after presenting some definitions of the concepts of human nature, which depict the complexity of these ...
Horodecka, Anna
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Where did anthropology go?: or the need for 'human nature' [PDF]
, 2004 I was recently asked the question: “Where did anthropology go? ” by a psycholinguist from a famous American university. She was commenting on the fact that she had tried to establish contact with the anthropology department of her institution, hoping ...
Bloch, Maurice
core +3 more sources