Results 71 to 80 of about 14,023,849 (296)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Thermal signatures of human pheromones in sexual and reproductive behaviour [PDF]

, 2010
Chemically mediated sexual communication in humans has been largely neglected due to its non-conscious and relatively concealed nature. However, menstrual cycle synchronisation, puberty onset in young pre-pubertal girls exposed to their stepfather, and ...
Andrea Mazzatenta, Gian Luca Romani, Luca Tommasi, Arcangelo Merla   +3 more
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Human Nature in Ancient Philosophy and its Influence On Modern Philosophy

Kalagatos
The concept of "human nature" is analyzed from the perspective of classical philosophy, with a focus on the thought of Mencius, a great Confucian philosopher.
Nguyen Thi Thu, Nguyen Van Thanh, Nguyen Minh Hoan   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Modeling roles and trade-offs in multiplex networks

Nature Communications
Multiplex social networks capture multiple types of relations among the same people. Their structure reflects how exchanges arise from individual attributes related to independence, the status or resources of others related to dependence, and mutual ...
Nikolaos Nakis, Sune Lehmann, Nicholas A. Christakis, Morten Mørup   +3 more
doaj   +1 more source

EXPLAINING AND VALUING: AN EXCHANGE BETWEEN THEOLOGY AND THE HUMAN SCIENCES

Zygon, 1995
. A comparison of E.O. Wilson's On Human Nature and Abraham Heschel's Who Is Man? introduces a discussion of how descriptions and explanations of the human are related to valuations of the human.
doaj   +2 more sources

Solidarity and human nature

Serviço Social em Revista, 2010
The concept of solidarity inhabits the collective unconscious and is usually related to something consensual, linked to the most basic values of mankind, but to expand that understanding leads to more complex views.
Luis Miguel dos Santos Luzio, Bernardo Carlos Spaulonci Chiachia Matos de Oliveira   +1 more
doaj   +1 more source