Results 51 to 60 of about 232,126 (306)

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection

Tumor Biology, 2017
It is known that high-risk human papillomavirus infection is the main etiological factor in cervical carcinogenesis. However, human papillomavirus screening is not sufficient for early diagnosis.
Song Qing, Wuniqiemu Tulake, Mingfang Ru, Xiaohong Li, Reziwanguli Yuemaier, Dilare Lidifu, Aierken Rouzibilali, Axiangu Hasimu, Yun Yang, Reziya Rouziahong, Halmurat Upur, Abulizi Abudula   +11 more
doaj   +1 more source

Evaluation of TypeSeq, a Novel High-Throughput, Low-Cost, Next-Generation Sequencing-Based Assay for Detection of 51 Human Papillomavirus Genotypes. [PDF]

, 2019
BackgroundHuman papillomaviruses (HPV) cause over 500 000 cervical cancers each year, most of which occur in low-resource settings. Human papillomavirus genotyping is important to study natural history and vaccine efficacy. We evaluated TypeSeq, a novel,
Boland, Joseph, Cortes, Bernal, Cullen, Michael, CVT Group, Dunn, S Terence, Herrero, Rolando, Hildesheim, Allan, Kreimer, Aimée R, Mirabello, Lisa, Porras, Carolina, Quint, Wim, Roberson, David, Rodriguez, Ana Cecilia, Sampson, Joshua, Schiffman, Mark, Van Doorn, Leen-Jan, Wagner, Sarah, Walker, Joan, Wentzensen, Nicolas, Yeager, Meredith, Zuna, Rosemary   +20 more
core   +1 more source

Cervical Cancer-Associated Human Papillomavirus 16 E7 Oncoprotein Inhibits Induction of Anti-Cancer Immunity by a CD4+ T Cell Dependent Mechanism [PDF]

, 2009
Attempts to develop therapeutic vaccines against cervical cancer have been proven difficult. One of the major causes of the failure is due to the use of the wrong mouse models based on transplantable tumours in testing the efficacy of vaccines.
Germain J. Fernando, Jie Zhong, Marion E. G. Brunck, Xiao Song Liu   +3 more
core   +2 more sources

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Presence of highly oncogenic human papillomavirus in the oral mucosa of asymptomatic men

Brazilian Journal of Infectious Diseases, 2014
Objectives: The aim of this study was to identify highly oncogenic forms of human papillomavirus in the oral mucosa of asymptomatic men. Methods: In this study, we analyzed samples of exfoliated cells from the oral cavity of 559 asymptomatic men.
Ana Paula Machado, Flávia Gatto de Almeida, Camila Mareti Bonin, Thiago Theodoro Martins Prata, Leandro Sobrinho Ávilla, Cacilda Tezelli Junqueira Padovani, Alda Maria Teixeira Ferreira, Carlos Eurico dos Santos Fernandes, Inês Aparecida Tozetti   +8 more
doaj   +1 more source

The retinoblastoma protein/p16INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma [PDF]

, 2011
Aims: The pathogenesis of penile squamous cell carcinoma (PSCC) is not well understood. Human papillomavirus (HPV) may be involved in carcinogenesis, but few studies have compared cell-cycle protein expression in HPV positive and negative cancers.
Backes, Bezerra, Bleeker, Cubilla, Daling, De Vuyst, Eichten, Ferreux, Fife, Funk, Funk, Gargiulo, Gartel, Gregoire, Guerrero, Hafkamp, Koyamatsu, Lam, Lam, Lont, Lopes, Lu, Martins, Munoz, Nam, Narayana, Nevins, Pascual, Prowse, Robinson, Rubin, Sano, Senba, Shoji, Sobin, Stankiewicz, Trimble, Vousden, Yanagawa   +38 more
core   +4 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Prevalence and genotype distribution of human papillomavirus infection among Kurdish people, Iran

SAGE Open Medicine
Background and aim: Human papillomavirus is a common sexually transmitted infection and a health concern, being the major cause of cervical cancer and genital warts.
Bahram Nikkhoo, Soma Mahmoodian, Pourya Bahrami, Arshia Daraee, Farzad Soleimani, Fatemeh Zamani, Sherko Nasseri, Khaled Rahmani   +7 more
doaj   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source