Results 241 to 250 of about 116,541 (310)

Safety, Tolerability, and Pharmacokinetics of GMDTC for Cadmium Poisoning: A Randomized Phase 1a/1b Trial

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 160-167, July 2026.
Cadmium exposure causes serious health consequences; however, there is no clinically approved antidote for cadmium poisoning. This Phase 1a/1b trial aimed to investigate safety, tolerability, and pharmacokinetics of Sodium (S)‐2‐(dithiocarboxylato((2S,3R,4R,5R)‐2,3,4,5,6‐pentahydroxyhexyl) amino)‐4‐(methylthio) butanoate (GMDTC), a novel chelating ...
Xuefeng Ren, Wei Hu, Xiaobin Deng, Rong Ma, Fang Pei, Xushen Chen, Xuemei Wang, Jixin Tang, Yan Lai, Shangming Pan, Zhiyong Zhong, Sheng Fu, Huamin Yuan, Juan Yuan, Chuntao Huang, Yuan Zeng, Xiaodong Ying, Guanghui Dong, Jinxin Zhang, Jinyuan Zhao, Kangguang Lin, Xiaojiang Tang   +21 more
wiley   +1 more source

Human papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA. [PDF]

J Virol
James CD, Youssef A, Prabhakar AT, Otoa R, Roe JD, Witt A, Lewis RL, Bristol ML, Wang X, Zhang K, Li R, Morgan IM.   +11 more
europepmc   +1 more source

Spontaneous regression of equine sarcoids is an exceptional event

Equine Veterinary Journal, Volume 58, Issue 4, Page 889-894, July 2026.
Abstract Sarcoids are benign, yet locally aggressive skin tumours that commonly affect horses and other equid species. The lesions are induced by bovine papillomavirus types 1, 2, and probably 13 in conjunction with other factors including trauma and a genetic predisposition.
Sabine Brandt
wiley   +1 more source

Unintended Consequences of Life‐Saving Pharmaceutical Innovations: How HAART Led to the Resurgence of Syphilis

Health Economics, Volume 35, Issue 7, Page 1118-1130, July 2026.
ABSTRACT Syphilis, a sexually transmitted infection that can lead to serious health complications, was almost eliminated in the United States by 2000. But since then, its incidence began to increase, recently reaching a 60‐year peak. We suggest that the introduction of the highly active antiretroviral therapy (HAART) drug regimen, which transformed HIV
David Beheshti, Scott Cunningham, Nir Eilam   +2 more
wiley   +1 more source

How Would You Treat? A Case‐Vignette Study of Provider Treatment Preferences in Human Papillomavirus‐Mediated Oropharyngeal Cancer

Head &Neck, Volume 48, Issue 7, Page 1770-1778, July 2026.
ABSTRACT Background Current guidelines recommend surgical resection, definitive radiotherapy (RT), or concurrent chemoradiotherapy (CRT) for human papillomavirus (HPV)‐associated oropharyngeal squamous cell carcinoma (OPSCC). This study aimed to provide insight into practice patterns of providers who treat HPV‐associated OPSCC.
Sindhura Sridhar, Michael R. Papazian, Michael C. Topf   +2 more
wiley   +1 more source

Downregulation of LAMB3 Altered the Carcinogenic Properties of Human Papillomavirus 16-Positive Cervical Cancer Cells. [PDF]

Int J Mol Sci
Wattanathavorn W, Seki M, Suzuki Y, Buranapraditkun S, Kitkumthorn N, Sasivimolrattana T, Bhattarakosol P, Chaiwongkot A.   +7 more
europepmc   +1 more source

Postoperative and Functional Outcomes of Oropharyngectomy in Irradiated Neck for Recurrent or Metachronous Squamous Cell Carcinoma

Head &Neck, Volume 48, Issue 7, Page 1885-1895, July 2026.
ABSTRACT Objective To evaluate predictors of postoperative and functional outcomes following salvage oropharyngectomy. Methods In this single‐center retrospective study, we included all patients who underwent an oropharyngectomy in an irradiated neck for recurrent or metachronous cancer between 2014 and 2023. Results We included 94 patients.
Jade Saykaly, Agnès Dupret‐Bories, Sébastien Vergez, Virginie Woisard, Benjamin Vairel, Jérôme Sarini, Ana Cavillon, Emilien Chabrillac   +7 more
wiley   +1 more source

Establishment and Characterization of Immortalized Human Dermal Papilla Cells Expressing Human Papillomavirus 16 E6/E7. [PDF]

J Microbiol Biotechnol
Kim S, Jeon KB, Park HM, Kim J, Lim CM, Yoon DY.   +5 more
europepmc   +1 more source

Deep Learning for Pretreatment Imaging‐Based Tumor and Nodal Classification in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Network Meta‐Analysis

Head &Neck, Volume 48, Issue 7, Page 1971-1983, July 2026.
ABSTRACT Background Accurate pretreatment assessment of the extent of tumor invasion and status of cervical lymph node metastasis is essential for staging and treatment planning in HNSCC. Deep learning (DL) shows promise but is limited by methodological heterogeneity. Methods We conducted a systematic review and network meta‐analysis (PRISMA). Studies (
Jannik Ketschau, Alex Grabenhorst, Hannes Singer, Johannes Brandt, Helena Kram, Nils Krautkremer, Maximilian F. Miragall, Katharina Pippich, Jonathan Mohr, Klaus‐Dietrich Wolff, Lucas M. Ritschl   +10 more
wiley   +1 more source

Evaluation of Ethyl Cellulose–Ethanol Ablation in a Human‐Sized 3D Construct of High‐Grade Cervical Dysplasia

Journal of Biomedical Materials Research Part A, Volume 114, Issue 7, July 2026.
ABSTRACT Current preclinical models for cervical dysplasia rely on animal systems that poorly mimic human anatomy. To address this and align with emerging initiatives to reduce animal experimentation, we developed a human‐sized, 3D in vitro model of high‐grade cervical dysplasia.
Gatha Adhikari, Alina Sharma, Kaitlin C. Fogg, Jenna L. Mueller   +3 more
wiley   +1 more source