Results 31 to 40 of about 44,207 (161)

Characterization of human parainfluenza virus type 3 persistent infection in cell culture [PDF]

Journal of Virology, 1990
Three cell lines persistently infected with human parainfluenza virus type 3 were characterized on a molecular level in this study. All six structural protein genes were transcribed into monocistronic RNAs in the persistently infected cells. In both acutely and persistently infected cells, polycistronic transcripts were abundant, although the ratio of ...
A, Moscona, M S, Galinski
openaire   +2 more sources

RNA editing in the phosphoprotein gene of the human parainfluenza virus type 3

Virology, 1992
RNA editing of the human parainfluenza virus type 3 (HPIV3) phosphoprotein (P) gene was found to occur for the accession of an alternate discontinuous cistron. Editing occurred within a purine-rich sequence (AAUUAAAAAAGGGGG) found at the mRNA nucleotides 791-805.
Galinski, Mark S., Troy, Roberta M., Banerjee, Amiya K.   +2 more
openaire   +2 more sources

Characterization of the Oligomerization Domain of the Phosphoprotein of Human Parainfluenza Virus Type 3

Virology, 2002
The phosphoprotein (P) of human parainfluenza virus type 3 (HPIV 3) plays a central role in the viral genome RNA transcription and replication. It acts as an essential cofactor of the RNA polymerase (L) by forming a functional L-P complex, binds to the genomic N-RNA template to recruit the L-P complex for RNA synthesis, and interacts with the ...
Choudhary, Suresh K., Malur, Achut G., Huo, Yunwen, De, Bishnu P., Banerjee, Amiya K.   +4 more
openaire   +2 more sources

Recovery of Infectious Human Parainfluenza Virus Type 3 from cDNA

Virology, 1997
Infectious HPIV3 was produced by the intracellular coexpression of four plasmid-borne cDNAs. These separately encoded a complete HPIV3 genome (negative-sense), the HPIV3 nucleocapsid protein N, the phosphoprotein P, and the polymerase protein L. The cDNA-encoded HPIV3 genome differed from the JS wildtype (wt) strain of HPIV3 used in its construction by
Durbin, Anna P., Hall, Susan L., Siew, Jeffrey W., Whitehead, Stephen S., Collins, Peter L., Murphy, Brian R.   +5 more
openaire   +2 more sources

Retinoic acid inducible gene I Activates innate antiviral response against human parainfluenza virus type 3

Virology Journal, 2009
Human parainfluenza virus type 3 (HPIV3) is a respiratory paramyxovirus that infects lung epithelial cells to cause high morbidity among infants and children.
Bose Santanu, Sabbah Ahmed
doaj   +1 more source

Antigenic variation of human and bovine parainfluenza virus type 3 strains

Journal of General Virology, 1990
Three human and six bovine parainfluenza virus type 3 (PIV3) strains were examined by the use of 60 monoclonal antibodies (MAbs). Fifty-three MAbs to the human C243 strain were directed against six, four, nine and seven epitopes of the haemagglutinin-neuraminidase (HN), fusion (F), nucleocapsid (N) and matrix proteins, respectively.
E, Klippmark, R, Rydbeck, H, Shibuta, E, Norrby   +3 more
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Inhibition of human parainfluenza virus type 3 infection by novel small molecules [PDF]

Antiviral Research, 2008
Human parainfluenza virus type 3 (HPIV3) is an important respiratory tract pathogen of infants and children. There are no vaccines or antivirals currently approved for prevention or treatment of HPIV3 infection. Towards developing an antiviral therapy to combat HPIV3 infection, we have established a green fluorescent protein (GFP)-tagged HPIV3 infected-
Hongxia, Mao, Chandar S, Thakur, Santanu, Chattopadhyay, Robert H, Silverman, Andrei, Gudkov, Amiya K, Banerjee   +5 more
openaire   +2 more sources

RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X

Cells, 2020
Viral disease is one of the greatest burdens for human health worldwide, with an urgent need for efficacious antiviral strategies. While antiviral drugs are available, in many cases, they are prone to the development of drug resistance. A way to overcome
Sundy N. Y. Yang, Sarah C. Atkinson, Michelle D. Audsley, Steven M. Heaton, David A. Jans, Natalie A. Borg   +5 more
doaj   +1 more source

Can epilepsy be predicted after the first febrile seizure? Insights from machine learning of postictal EEG

Epileptic Disorders, EarlyView.
Abstract Objective Febrile seizures (FS) are the most common seizures in childhood, yet identifying children at risk of developing epilepsy after the first FS remains challenging. We aimed to evaluate the prognostic potential of machine learning (ML) algorithms applied to post‐febrile seizure electroencephalography (EEG) recordings.
Boran Şekeroğlu, Hüseyin Öztoprak, Özlem Yayıcı Köken, Hatice Demir, Mehpare Sarı Yanartaş, Deniz Yılmaz, Burçin Şanlıdağ, Ayşegül Neşe Çıtak Kurt   +7 more
wiley   +1 more source

Reusing health records from farm animal practices at scale: A potential complementary method of surveillance

Veterinary Record, EarlyView.
Abstract Background Disease in primary care frequently represents a surveillance blind spot, particularly for diseases affecting farm animals. Methods Electronic health records (EHRs) were collected from four farm animal veterinary practices in Wales (February 2024‒January 2025) as part of a pilot study.
Beverley Hopkins, Peers Davies, Peter‐John Noble, Anna Bunford‐Davies, April Lawson, Gina Pinchbeck, Ifan Lloyd, Robert Smith, Alan D. Radford   +8 more
wiley   +1 more source