Results 11 to 20 of about 44,207 (161)

Involvement of Actin-Regulating Factor Cofilin in the Inclusion Body Formation and RNA Synthesis of Human Parainfluenza Virus Type 3 via Interaction With the Nucleoprotein [PDF]

Frontiers in Microbiology, 2019
Human parainfluenza virus type 3 (HPIV3) is one of the primary pathogens that causing severe respiratory tract diseases in newborns and infants. It could induce inclusion bodies (IBs) in infected cells.
Yinshuang Li, Yinshuang Li, Chaoliang Zhang, Chaoliang Zhang, Nan Lu, Xichuan Deng, Guangchao Zang, Shengwei Zhang, Hong Tang, Guangyuan Zhang   +9 more
doaj   +2 more sources

Inclusion bodies of human parainfluenza virus type 3 inhibit antiviral stress granule formation by shielding viral RNAs. [PDF]

PLoS Pathogens, 2018
Viral invasion triggers the activation of the host antiviral response. Besides the innate immune response, stress granules (SGs) also act as an additional defense response to combat viral replication. However, many viruses have evolved various strategies
Zhulong Hu, Yuang Wang, Qiaopeng Tang, Xiaodan Yang, Yali Qin, Mingzhou Chen   +5 more
doaj   +2 more sources

Human parainfluenza virus type 3 expressing the respiratory syncytial virus pre-fusion F protein modified for virion packaging yields protective intranasal vaccine candidates. [PDF]

PLoS ONE, 2020
Human respiratory syncytial virus (RSV) and parainfluenza virus type 3 (HPIV3) are among the most common viral causes of childhood bronchiolitis and pneumonia worldwide, and lack effective antiviral drugs or vaccines.
Xueqiao Liu, Bo Liang, Xiang Liu, Emerito Amaro-Carambot, Sonja Surman, Peter D Kwong, Barney S Graham, Peter L Collins, Shirin Munir   +8 more
doaj   +2 more sources

Human Parainfluenza Virus Type 3 Matrix Protein Reduces Viral RNA Synthesis of HPIV3 by Regulating Inclusion Body Formation [PDF]

Viruses, 2018
Human parainfluenza virus type 3 is one of the main causes of lower respiratory illness in newborns and infants. The role of the matrix protein (M) in viral budding is extensively studied, but the effect of M on viral replication remains to be determined.
Shengwei Zhang, Qi Cheng, Chenxi Luo, Yali Qin, Mingzhou Chen   +4 more
doaj   +2 more sources

Inefficient antiviral response in reconstituted small-airway epithelium from chronic obstructive pulmonary disease patients following human parainfluenza virus type 3 infection [PDF]

Virology Journal
Chronic obstructive pulmonary disease (COPD) affects over 250 million individuals globally and stands as the third leading cause of mortality. Respiratory viral infections serve as the primary drivers of acute exacerbations, hastening the decline in lung
Louise Bondeelle, Maud Salmona, Véronique Houdouin, Elise Diaz, Jacques Dutrieux, Séverine Mercier-Delarue, Samuel Constant, Song Huang, Anne Bergeron, Jérôme LeGoff   +9 more
doaj   +2 more sources

Mutations in the DI-DII Linker of Human Parainfluenza Virus Type 3 Fusion Protein Result in Diminished Fusion Activity. [PDF]

PLoS ONE, 2015
Human parainfluenza virus type 3 (HPIV3) can cause severe respiratory tract diseases in infants and young children, but no licensed vaccines or antiviral agents are currently available for treatment.
Wenyan Xie, Hongling Wen, Fulu Chu, Shaofeng Yan, Bin Lin, Wenli Xie, Ying Liu, Guijie Ren, Li Zhao, Yanyan Song, Chengxi Sun, Zhiyu Wang   +11 more
doaj   +2 more sources

Landscape of Prophylactic Strategies Against Human Parainfluenza Virus Type 3. [PDF]

Rev Med Virol
ABSTRACT Human parainfluenza virus‐type 3 (HPIV3) is a respiratory virus responsible for mild illnesses in most of the population and severe illnesses, such as bronchiolitis and pneumonia, in young children, immunocompromised individuals and the elderly.
Vacher C, Dubois J, Hamelin ME, Boivin G, Rosa-Calatrava M.   +4 more
europepmc   +3 more sources

Inflammasome Antagonism by Human Parainfluenza Virus Type 3 C Protein. [PDF]

J Virol, 2018
ABSTRACT Human parainfluenza virus type 3 (HPIV3) is a negative-sense single-stranded RNA virus belonging to the Paramyxoviridae family. HPIV3 is a lung-tropic virus causing airway diseases, including pneumonia, croup, and bronchiolitis, during infancy and childhood.
Shil NK, Pokharel SM, Banerjee AK, Hoffman M, Bose S.   +4 more
europepmc   +4 more sources

Mechanism of Interference Mediated by Human Parainfluenza Virus Type 3 Infection [PDF]

Journal of Virology, 2000
ABSTRACT Viral interference is characterized by the resistance of infected cells to infection by a challenge virus. Mechanisms of viral interference have not been characterized for human parainfluenza virus type 3 (HPF3), and the possible role of the neuraminidase (receptor-destroying) enzyme of the hemagglutinin-neuraminidase (HN ...
Horga, M. A, Gusella, G. L, Greengard, O, Poltoratskaia, N, Porotto, M, Moscona, A.   +5 more
openaire   +5 more sources

An infectious clone of human parainfluenza virus type 3 [PDF]

Journal of Virology, 1997
A full-length clone of the human parainfluenza virus type 3 (HPIV-3) genome (called pHPIV-3) was constructed, and recombinant, infectious HPIV-3 was generated by transfecting pHPIV-3 and support plasmids encoding the HPIV-3 NP, P, and L proteins into HeLa cells infected with a vaccinia virus recombinant which expresses T7 RNA polymerase.
M A, Hoffman, A K, Banerjee
openaire   +2 more sources