Results 101 to 110 of about 1,669,866 (339)

MultiNeuron - Neural Networks Simulator for Medical, Physiological, and Psychological Applications [PDF]

open access: yes, 1995
This work describes neural software applied in medicine and physiology to: - investigate and diagnose immune deficiencies; diagnose and study allergic and pseudoallergic reactions; forecast emergence or aggravation of stagnant cardiac insufficiency in ...
Dorrer, Mikhail G.   +2 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

The ins and outs of liver fat metabolism: The effect of phenotype and diet on risk of intrahepatic triglyceride accumulation

open access: yesExperimental Physiology
In health, the liver is a metabolically flexible organ that plays a key role in regulating systemic lipid and glucose concentrations. There is a constant flux of fatty acids (FAs) to the liver from multiple sources, including adipose tissue, dietary ...
Kieran Smith   +2 more
doaj   +1 more source

Comparative efficacy of various exercise therapies for chronic fatigue syndrome: A systematic review and network meta-analysis

open access: yesiScience
Summary: To systematically compare the effectiveness of different exercise therapies for chronic fatigue syndrome (CFS), we conducted a systematic review and network meta-analysis of randomized controlled trials based on searches of nine databases up to ...
Zhongxin Liao   +6 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

The impact of the 1938 fascist anti-Semitic legislation on the development of physiology in Italian universities following replacement of five full professors

open access: yesAdvances in Physiology Education
The effects of the 1938 fascist anti-Semitic laws on the development of physiology in Italy are discussed, focusing on the replacement of five full professors of human physiology expelled from the Universities of Bologna, Milan, Turin, Genoa, and Palermo.
Pompeo Volpe   +2 more
doaj   +1 more source

Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

open access: yesNature Communications, 2017
Metabolic diseases have been associated with cognitive impairment. Here, the authors show that brain insulin resistance induced by high-fat diet leads to increased palmitoylation of AMPA receptors and thus changes in hippocampal plasticity, learning and ...
Matteo Spinelli   +12 more
doaj   +1 more source

An interactive triangle approach to student learning [PDF]

open access: yes, 2005
Report of a CELT project on enhancing learning and teaching through innovation and research.Discusses the findings of a research project designed to improve student performance through innovative learning and teaching methods.
Barrow, Paul   +3 more
core   +1 more source

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