Results 181 to 190 of about 720,906 (256)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Understanding oxytocin in human physiology and pathophysiology: A path towards therapeutics. [PDF]

Compr Psychoneuroendocrinol
Lawson EA.
europepmc   +1 more source

Organic Cation Transporters in Human Physiology, Pharmacology, and Toxicology. [PDF]

Int J Mol Sci, 2020
Samodelov SL, Kullak-Ublick GA, Gai Z, Visentin M.   +3 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Revitalising Riboflavin: Unveiling Its Timeless Significance in Human Physiology and Health. [PDF]

Foods
Aragão MÂ, Pires L, Santos-Buelga C, Barros L, Calhelha RC.   +4 more
europepmc   +1 more source

In sickness and health: Effects of gut microbial metabolites on human physiology. [PDF]

PLoS Pathog, 2020
Glowacki RWP, Martens EC.
europepmc   +1 more source

Human Physiology [PDF]

The American Naturalist, 1901
openaire   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Myths and methodologies: Assessing glycaemic control and associated regulatory mechanisms in human physiology research. [PDF]

Exp Physiol
Wrench E, Subar DA, Bampouras TM, Lauder RM, Gaffney CJ.   +4 more
europepmc   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source