Results 161 to 170 of about 11,822,869 (333)
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Scientific ReportsRise of antibiotic resistance has led to increased treatment failures in severe cholera cases across the globe. The etiological agent Vibrio cholerae is known for its ability to persist in human gut and environmental settings through biofilm formation ...
Tuhin Manna +11 more
doaj +1 more source
Editorial: Artificial intelligence in human physiology. [PDF]
Front Physiol, 2022 Ong CS, Burattini L, Schena S.
europepmc +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Alternative Splicing in Human Physiology and Disease. [PDF]
Genes (Basel), 2022 Artemaki PI, Kontos CK.
europepmc +1 more source
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Medical students' perceptions of factors that Impact their performance in human physiology course: suggestions for improving course presentation. [PDF]
BMC Med Educ, 2023 Halalsheh R, Al-Rawashdeh A, Rababah E.
europepmc +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Impact of a peer-to-peer escape room activity in the learning of Human Physiology of medical students from the university of Málaga. [PDF]
Front Physiol, 2023 Carrasco-Gomez D +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source