Results 141 to 150 of about 11,822,869 (333)
Adaptation of sleep to daylight saving time is slower in people consuming a high-fat diet
iScienceSummary: Adaptation of the circadian clock to the environment is essential for optimal health, well-being, and performance. Animal models demonstrate that a high-fat diet impairs circadian adaptation to advances of the light-dark cycle; it is unknown ...
Andrew W. McHill +5 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
BMC Complementary Medicine and TherapiesBackground Staphylococcus aureus, member of ESKAPEE pathogens is a noteworthy contributor to the global crisis rising due to antimicrobial resistance. Biofilms are the primary reason behind the increased antibiotic resistance and tolerance of pathogens ...
Debarati Jana +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Frontiers in Vascular Physiology _ Speciality Section of Frontiers in Physiology
, 2012 Frontiers in Vascular Physiology is a Specialty Section of Frontiers in Physiology. It is devoted to embracing the field of vascular physiology with all its many facets from the molecular to the intact system level.
ZOCCOLI, GIOVANNA
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
A study of a marsupial olfactory system : its electrical activity and modification by drugs [PDF]
, 1974 [161] leaves : ill., photos, graphs ; 30 cm.Thesis (Ph.D.)--University of Adelaide, Dept.
Wilson, Peter Robert
core
How consumer physical activity monitors could transform human physiology research.
American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2017 S. P. Wright +3 more
semanticscholar +1 more source
BMC MicrobiologyBackground Staphylococcus aureus and Staphylococcus epidermidis are tenacious pathogens that cause toxic shock syndrome. Accessory gene regulator (Agr) of Staphylococcus sp.
Subhamoy Dey +10 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source