Results 151 to 160 of about 720,906 (256)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Across species: A comparative perspective on red cell homeostasis and its influence on our understanding of human physiology and disease. [PDF]

Br J Haematol
Connolly KM, Ding P, Wadud R, Rees DC, Brewin JN, Gibson JS.   +5 more
europepmc   +1 more source

Impacts of Changes in Atmospheric O₂ on Human Physiology. Is There a Basis for Concern? [PDF]

Front Physiol, 2021
Keeling RF, Powell FL, Shaffer G, Robbins PA, Simonson TS.   +4 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

A Biochemical View on Intermittent Fasting's Effects on Human Physiology-Not Always a Beneficial Strategy. [PDF]

Biology (Basel)
Zambuzzi WF, Ferreira MR, Wang Z, Peppelenbosch MP.   +3 more
europepmc   +1 more source

Mice as experimental models for human physiology: when several degrees in housing temperature matter. [PDF]

Nat Metab, 2021
Seeley RJ, MacDougald OA.
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Human Physiology

Nature, 1911
Luigi Luciani, Marie. Camis, Marcus Seymour Pembrey, Frances A. Welby, Gordon Holmes   +4 more
openaire   +4 more sources

Autonomous slip control inspired by human physiology for improved shared control strategy. [PDF]

Wearable Technol
Matos J, Capsi-Morales P, Piazza C.
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source