Results 31 to 40 of about 8,792,528 (401)

Revisiting Steroidogenic Pathways in the Human Placenta and Primary Human Trophoblast Cells

International Journal of Molecular Sciences, 2021
Steroid hormones play a crucial role in supporting a successful pregnancy and ensuring proper fetal development. The placenta is one of the principal tissues in steroid production and metabolism, expressing a vast range of steroidogenic enzymes ...
Rona Karahoda, Sampada Kallol, M. Groessl, E. Ontsouka, P. Anderle, Christa E. Fluck, F. Staud, C. Albrecht   +7 more
semanticscholar   +1 more source

Placental development and preeclampsia

生物医学转化, 2022
Serving as the interface between the fetal and maternal environment during gestation, the placenta plays critical roles in the protection of the developing fetus and the maintenance of pregnancy.
Zhu Yuelin, Li Qianqian, Wang Yanling, Shao Xuan   +3 more
doaj   +1 more source

Isolation and characterization of galectin-1 binding proteins from human placenta [PDF]

Journal of the Serbian Chemical Society, 2000
Galectin-1 binding proteins were isolated from human placenta by affinity chromatography on a column with immobilized endogenous lectin. The molecular masses of the isolated proteins of 170, 67 and 56 kDa were estimated by gel filtration and SDS-
Janković Miroslava
doaj   +3 more sources

Comparative Study of PPARγ Targets in Human Extravillous and Villous Cytotrophoblasts

PPAR Research, 2020
Trophoblasts, as the cells that make up the main part of the placenta, undergo cell differentiation processes such as invasion, migration, and fusion.
Fulin Liu, Christine Rouault, Mickael Guesnon, Wencan Zhu, Karine Clément, Séverine A. Degrelle, Thierry Fournier   +6 more
doaj   +1 more source

Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Defects in development and differentiation of the placenta are associated with various pregnancy disorders such as miscarriage, stillbirth, preeclampsia, and intrauterine growth restriction.
G. Meinhardt, S. Haider, V. Kunihs, L. Saleh, J. Pollheimer, C. Fiala, Szabolcs Hetey, Zsofia Feher, A. Szilágyi, N. Than, M. Knöfler   +10 more
semanticscholar   +1 more source

The human placenta methylome [PDF]

Proceedings of the National Academy of Sciences, 2013
Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also over larger genomic regions. In most human tissues, the vast majority of the genome is highly methylated (>70%). Recently, sequencing of bisulfite-treated DNA (MethylC-seq) has revealed large partially methylated domains (PMDs) in some human cell lines.
Paul Ashwood, John D. Blair, Wendy P. Robinson, Hung On Ken Yu, Paul Lott, Danna Hong, Diane I. Schroeder, Janine M. LaSalle, Ian F Korf, Cheryl Walker, Florence K. Crary   +10 more
openaire   +2 more sources

Trophoblast lineage-specific differentiation and associated alterations in preeclampsia and fetal growth restriction. [PDF]

, 2020
The human placenta is a poorly-understood organ, but one that is critical for proper development and growth of the fetus in-utero. The epithelial cell type that contributes to primary placental functions is called "trophoblast," including two main ...
Farah, Omar, Nguyen, Calvin, Parast, Mana M, Tekkatte, Chandana   +3 more
core   +2 more sources

Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

bioRxiv, 2020
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected over 3.8 million people, including pregnant women.
R. Pique-Regi, R. Romero, A. Tarca, Francesca Luca, Yi Xu, A. Alazizi, Y. Leng, Chaur-Dong Hsu, N. Gomez‐Lopez   +8 more
semanticscholar   +1 more source

Mesenchymal Stromal Cells from Fetal and Maternal Placenta Possess Key Similarities and Differences: Potential Implications for Their Applications in Regenerative Medicine

Cells, 2020
Placenta-derived mesenchymal stromal cells (MSC) have attracted more attention for their immune modulatory properties and poor immunogenicity, which makes them suitable for allogeneic transplantation.
Andrea Papait, Elsa Vertua, Marta Magatti, Sabrina Ceccariglia, Silvia De Munari, Antonietta Rosa Silini, Michal Sheleg, Racheli Ofir, Ornella Parolini   +8 more
doaj   +1 more source

Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA Sequencing

Cells, 2022
Background: The placenta is an important organ for fetal and maternal health during pregnancy and impacts offspring health late in life. Defects in placental vasculature and trophoblast have been identified in several pregnancy complications.
Han Li, Hao Peng, Wei Hong, Yingying Wei, Haojun Tian, Xiaojie Huang, Linyan Jia, Jing Zheng, Tao Duan, Qizhi He, Kai Wang   +10 more
doaj   +1 more source