Results 61 to 70 of about 8,144,169 (239)
Advanced Science, EarlyView.Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu +6 more
wiley +1 more source
Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis
Advanced Science, EarlyView.CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan +13 more
wiley +1 more source
Platelet kinetics in the pulmonary microcirculation in vivo assessed by intravital microscopy [PDF]
, 2002 Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet.
Eichhorn, M. E. +4 more
core +1 more source
Advanced Science, EarlyView.The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu +4 more
wiley +1 more source
, 2015 [No abstract available]343180181Castro, V., Origa, A.F., Annichino-Bizzacchi, J.M., Soares, M., Menezes, R.C., Gonçalves, M.S., Frequencies of platelet-specific alloantigen systems 1-5 in three distinct ethnic groups in Brazil (1999) Eur J Immunogenet ...
de Paula, Erich Vinicius, de Paula E.V.
core +1 more source
N-terminal sequence of human leukocyte glycoprotein Mol: conservation across species and homology to platelet IIb/IIIa [PDF]
, 1986 Mo1 and gp160-gp93 are two surface membrane glycoprotein heterodimers present on granulocytes and monocytes derived from humans and guinea pigs, respectively.
Remold-O'Donnell, Eileen +3 more
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Advanced Science, EarlyView.A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu +6 more
wiley +1 more source
Role of P-selectin in platelet sequestration in pulmonary capillaries during endotoxemia [PDF]
, 2006 Background: There is growing evidence that platelets accumulate in the lung and contribute to the pathogenesis of acute lung injury during endotoxemia.
Schenkat, Sonja +4 more
core +1 more source
Advanced Science, EarlyView.A HER3‐targeted sonogenetic lipid nanoparticle platform is developed for triple‐negative breast cancer therapy. An AI‐designed miniprotein inhibits HER3 signaling, while TRPV4 and NFAT‐responsive IL‐15 plasmids enable ultrasound‐controlled calcium signaling and cytokine expression. The system induces Ca2+ overload, ROS generation, mitochondrial damage,
Junya Song +6 more
wiley +1 more source
, 2014 International audiencePlatelet refractoriness is a serious complication for patients receiving recurrent platelet transfusions, which can be explained by non-immune and immune causes.
Basire, A, Picard, Christophe
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