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The pathogenesis and tissue damage that accompanies destruction of platelets in immune thrombocytopenias (IT) is still not understood very well and in addition to platelets, other cells (e.g.
Mariusz Z Ratajczak +5 more
doaj +4 more sources
Human Platelet Antigen Genotyping and Expression of CD109 (Human Platelet Antigen 15) mRNA in Various Human Cell Types [PDF]
CD109 gene encodes a glycosylphosphatidylinositol-linked glycoprotein found in a subset of platelets and endothelial cell, and human platelet antigen (HPA) 15 is found on CD109. We evaluated the HPA genotype and/or the CD109 mRNA expression on two peripheral blood stem cells (PBSC), two peripheral bloods (PB), 12 granulocyte products, natural killer ...
Hwang, Sang Mee +8 more
openaire +2 more sources
ObjectiveTransfusion of HLA-matched platelets can reduce the effect of alloimmune responses on platelet transfusion efficacy; however, finding HLA-matched platelets in the population is nearly impossible. Almost all HLA-matched platelets from related are
Jing-Cheng Zhang +3 more
doaj +1 more source
Determination of platelet antigens and glycoproteins in the human fetus [PDF]
The autosomal recessive transmission of Glanzmann's thrombasthenia (GT) and Bernard-Soulier syndrome (BSS), together with requests of families who already had children with these diseases, prompted us to investigate the feasibility of their antenatal diagnosis. The preliminary step leading to the early detection of GT or BSS was to characterize, in the
Y, Gruel +5 more
openaire +3 more sources
BACKGROUND: Immune platelet refractoriness is mainly caused by human leukocyte antigen antibodies (80-90% of cases) and, to a lesser extent, by human platelet antigen antibodies.
Carolina Bonet Bub +5 more
doaj +1 more source
Factor XI antigen and activity in human platelets [PDF]
Abstract Washed platelets, contaminated with less than 0.20% plasma factor XI, were examined for the presence of factor XI antigen and activity. These platelets contained a factor-XI-like coagulant activity (0.67 +/- 0.11 U/10(11) platelets) that remained constant after successive washes.
G P, Tuszynski +4 more
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Neonatal Alloimmune Thrombocytopenia Detected After Traumatic Delivery: Case Report
Neonatal Alloimmune Thrombocytopenia (NAIT), a complication of maternal alloimmunization against fetal platelets, is the result of immune destruction of platelets due to maternal antibodies in the early period.
Gökhan Kaya, Sema Tanriverdi
doaj +1 more source
Association of human platelet antigen polymorphisms with platelet count and mean platelet volume [PDF]
Although recent genome-wide association studies have identified a number of single nucleotide polymorphisms associated with platelet count and mean platelet volume (MPV), it is unclear whether polymorphisms in the human platelet antigens (HPA) genes are associated with platelet count and MPV.
Shihang, Zhou +5 more
openaire +2 more sources
Foetal and neonatal alloimune thrombocytopenia as a rare exapmle of thrombocytopenia in newborn
Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by antigenic incompatibility of platelets between a pregnant woman and her child, resulting in producing antibodies by a mother against specific antigens (HPA- Human Platelet Antigens ...
Maciej Kamiński +6 more
doaj +3 more sources
Platelet antibodies identification: comparison between two laboratory tests
Introduction: Platelet antibody identification is indispensable for diagnosing the human platelet antigen (HPA) or human leukocyte antigen (HLA) immunization, mostly because it can restrict the compatibility and results of transfusions. Correct detection
Valeria de Freitas Dutra +6 more
doaj +1 more source

