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Evidence that platelet-derived microvesicles may transfer platelet-specific immunoreactive antigens to the surface of endothelial cells and CD34+ hematopoietic stem/ progenitor cells--implication for the pathogenesis of immune thrombocytopenias.

open access: yesFolia Histochemica et Cytobiologica, 2007
The pathogenesis and tissue damage that accompanies destruction of platelets in immune thrombocytopenias (IT) is still not understood very well and in addition to platelets, other cells (e.g.
Mariusz Z Ratajczak   +5 more
doaj   +4 more sources

Human Platelet Antigen Genotyping and Expression of CD109 (Human Platelet Antigen 15) mRNA in Various Human Cell Types [PDF]

open access: yesBioMed Research International, 2013
CD109 gene encodes a glycosylphosphatidylinositol-linked glycoprotein found in a subset of platelets and endothelial cell, and human platelet antigen (HPA) 15 is found on CD109. We evaluated the HPA genotype and/or the CD109 mRNA expression on two peripheral blood stem cells (PBSC), two peripheral bloods (PB), 12 granulocyte products, natural killer ...
Hwang, Sang Mee   +8 more
openaire   +2 more sources

Related donor platelet transfusion improves platelet transfusion refractoriness in hematological patients

open access: yesFrontiers in Medicine, 2023
ObjectiveTransfusion of HLA-matched platelets can reduce the effect of alloimmune responses on platelet transfusion efficacy; however, finding HLA-matched platelets in the population is nearly impossible. Almost all HLA-matched platelets from related are
Jing-Cheng Zhang   +3 more
doaj   +1 more source

Determination of platelet antigens and glycoproteins in the human fetus [PDF]

open access: yesBlood, 1986
The autosomal recessive transmission of Glanzmann's thrombasthenia (GT) and Bernard-Soulier syndrome (BSS), together with requests of families who already had children with these diseases, prompted us to investigate the feasibility of their antenatal diagnosis. The preliminary step leading to the early detection of GT or BSS was to characterize, in the
Y, Gruel   +5 more
openaire   +3 more sources

Platelet antibody detection by flow cytometry: an effective method to evaluate and give transfusional support in platelet refractoriness

open access: yesRevista Brasileira de Hematologia e Hemoterapia, 2013
BACKGROUND: Immune platelet refractoriness is mainly caused by human leukocyte antigen antibodies (80-90% of cases) and, to a lesser extent, by human platelet antigen antibodies.
Carolina Bonet Bub   +5 more
doaj   +1 more source

Factor XI antigen and activity in human platelets [PDF]

open access: yesBlood, 1982
Abstract Washed platelets, contaminated with less than 0.20% plasma factor XI, were examined for the presence of factor XI antigen and activity. These platelets contained a factor-XI-like coagulant activity (0.67 +/- 0.11 U/10(11) platelets) that remained constant after successive washes.
G P, Tuszynski   +4 more
openaire   +3 more sources

Neonatal Alloimmune Thrombocytopenia Detected After Traumatic Delivery: Case Report

open access: yesForbes Tıp Dergisi, 2021
Neonatal Alloimmune Thrombocytopenia (NAIT), a complication of maternal alloimmunization against fetal platelets, is the result of immune destruction of platelets due to maternal antibodies in the early period.
Gökhan Kaya, Sema Tanriverdi
doaj   +1 more source

Association of human platelet antigen polymorphisms with platelet count and mean platelet volume [PDF]

open access: yesHematology, 2018
Although recent genome-wide association studies have identified a number of single nucleotide polymorphisms associated with platelet count and mean platelet volume (MPV), it is unclear whether polymorphisms in the human platelet antigens (HPA) genes are associated with platelet count and MPV.
Shihang, Zhou   +5 more
openaire   +2 more sources

Foetal and neonatal alloimune thrombocytopenia as a rare exapmle of thrombocytopenia in newborn

open access: yesJournal of Education, Health and Sport, 2018
Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by antigenic incompatibility of platelets between a pregnant woman and her child, resulting in producing antibodies by a mother against specific antigens (HPA- Human Platelet Antigens ...
Maciej Kamiński   +6 more
doaj   +3 more sources

Platelet antibodies identification: comparison between two laboratory tests

open access: yesHematology, Transfusion and Cell Therapy, 2022
Introduction: Platelet antibody identification is indispensable for diagnosing the human platelet antigen (HPA) or human leukocyte antigen (HLA) immunization, mostly because it can restrict the compatibility and results of transfusions. Correct detection
Valeria de Freitas Dutra   +6 more
doaj   +1 more source

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