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Prevalence and Specificity of Anti-HPA and Anti-HLA Antibodies in Patients with Suspected Immune-Mediated Platelet Disorders: A Single-Center Study from Serbia [PDF]

Medicina
Background and Objectives: Alloantibodies directed against human platelet antigens and human leukocyte antigens are implicated in several immune-mediated platelet disorders, including platelet transfusion refractoriness, post-transfusion purpura and ...
Svetlana Vojvodić, Jasmina Grujić
doaj   +2 more sources

Evidence that platelet-derived microvesicles may transfer platelet-specific immunoreactive antigens to the surface of endothelial cells and CD34+ hematopoietic stem/ progenitor cells--implication for the pathogenesis of immune thrombocytopenias. [PDF]

Folia Histochemica et Cytobiologica, 2007
The pathogenesis and tissue damage that accompanies destruction of platelets in immune thrombocytopenias (IT) is still not understood very well and in addition to platelets, other cells (e.g.
Mariusz Z Ratajczak, Barbara Zupanska, Jolanta Goźdizk, Ewa Lesko, Jacek Kijowski, Marcin Majka   +5 more
doaj   +4 more sources

Fc galactosylation of anti-platelet human IgG1 alloantibodies enhances complement activation on platelets

Haematologica, 2022
Approximately 20% of patients receiving multiple platelet transfusions develop platelet alloantibodies, which can be directed against human leukocyte antigens (HLA) and, to a lesser extent, against human platelet antigens (HPA).
Thijs L.J. van Osch, Janita J. Oosterhoff, Arthur E. H. Bentlage, Jan Nouta, Carolien A. M. Koeleman, Dionne M. Geerdes, Juk Yee Mok, Sebastiaan Heidt, Arend Mulder, Wim J. E. van Esch, Rick Kapur, Leendert Porcelijn, C. Ellen van der Schoot, Masja de Haas, Manfred Wuhrer, Jan Voorberg, Gestur Vidarsson   +16 more
doaj   +1 more source

Genotyping of Human Platelet Antigen-1 to -5 and -15 by Polymerase Chain Reaction with Sequence-specific Primers (PCR-SSP) and Real-time PCR in Azeri Blood Donors

Iranian Journal of Allergy, Asthma and Immunology, 2021
Human platelet antigens (HPAs) are glycoproteins on the platelet surface that a single nucleotide mutation in the coding region gene could lead to the variation of different HPA polymorphisms. These antigens have shown variation among different races and
Seyed Ghader Azizi, Shahram Samiee, Mojgan Shaiegan, Maryam Zadsar   +3 more
doaj   +1 more source

Association of the human platelet antigens polymorphisms with platelet count in patients with COVID-19

Frontiers in Medicine, 2023
Polymorphism in human platelet antigen (HPA)-1 and HPA-3 (GPIIb/IIIa), HPA-2 (GPIb/IX), HPA-4 (GPIIIa), HPA-5 (GPIa/IIa), & HPA-15 (CD109) was investigated in 86 COVID-19-infected patients with thrombocytopenia (Group A) and 136 COVID-19-infected ...
Kazem Ghaffari, Kazem Ghaffari, Mahsa Ashrafi Rad, Amin Moradi Hasan-Abad, Mersedeh Khosravi, Arefeh Benvidi, Mahsa Iraji, Heidar Ali Heidari Khargh, Ali Ghasemi, Ali Ghasemi   +9 more
doaj   +1 more source

Simultaneous genotyping for human platelet antigen systems and HLA-A and HLA-B loci by targeted next-generation sequencing

Frontiers in Immunology, 2022
In order to treat the alloimmunization platelet transfusion refractoriness (PTR), human leukocyte antigen (HLA)-type and/or human platelet antigen (HPA)-type matched platelets between donors and patients are usually used.
Jielin Wang, Jielin Wang, Xuan You, Xuan You, Yanmin He, Yanmin He, Xiaozhen Hong, Xiaozhen Hong, Ji He, Ji He, Sudan Tao, Sudan Tao, Faming Zhu, Faming Zhu   +13 more
doaj   +1 more source

Platelet transfusion refractoriness in patients with acute myeloid leukemia: The role of anti-platelet antibodies [PDF]

Srpski Arhiv za Celokupno Lekarstvo
Introduction/Objective. Platelet transfusion refractoriness represents a common issue in the treatment course of acute myeloid leukemia (AML) patients who require chronic transfusion support.
Đunić Irena, Srdić-Rajić Tatjana, Pantić Nikola, Todorović-Balint Milena   +3 more
doaj   +1 more source

Related donor platelet transfusion improves platelet transfusion refractoriness in hematological patients

Frontiers in Medicine, 2023
ObjectiveTransfusion of HLA-matched platelets can reduce the effect of alloimmune responses on platelet transfusion efficacy; however, finding HLA-matched platelets in the population is nearly impossible. Almost all HLA-matched platelets from related are
Jing-Cheng Zhang, Li-Hong Ni, Yan Tu, Hui-Xian Hu   +3 more
doaj   +1 more source

Platelet antibody detection by flow cytometry: an effective method to evaluate and give transfusional support in platelet refractoriness

Revista Brasileira de Hematologia e Hemoterapia, 2013
BACKGROUND: Immune platelet refractoriness is mainly caused by human leukocyte antigen antibodies (80-90% of cases) and, to a lesser extent, by human platelet antigen antibodies.
Carolina Bonet Bub, Beatriz Moraes Martinelli, Thayna Mendonca Avelino, Ana Claudia Goncalez, Maria de Lourdes Barjas-Castro, Vagner Castro   +5 more
doaj   +1 more source

Neonatal Alloimmune Thrombocytopenia Detected After Traumatic Delivery: Case Report

Forbes Tıp Dergisi, 2021
Neonatal Alloimmune Thrombocytopenia (NAIT), a complication of maternal alloimmunization against fetal platelets, is the result of immune destruction of platelets due to maternal antibodies in the early period.
Gökhan Kaya, Sema Tanriverdi
doaj   +1 more source