Results 91 to 100 of about 2,756,930 (359)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

Green human resource management: An organisational strategy for Greening employees [PDF]

open access: yes, 2018
Global warming is a reality. Organisations realise their corporate responsibility to conduct their business with the 'future' in mind. Further, organisations realise that going green is a smart organisational strategy (Mandip, 2012).
Storm, Esti, Taylor, Beverly
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

ACTIONS FOR THE TRAINING OF THE HUMAN RESOURCES OF THE MUNICIPAL STRUCTURES OF THE MISSION ROBINSON IN THE STATE COJEDES OF THE BOLIVARIAN REPUBLIC OF VENEZUELA / ACCIONES PARA LA CAPACITACIÓN DE LOS RECURSOS HUMANOS DE LAS ESTRUCTURAS MUNICIPALES DE LA MISIÓN ROBINSON EN EL ESTADO COJEDES DE LA REPÚBLICA BOLIVARIANA DE VENEZUELA

open access: yesDidasc@lia: didáctica y educación, 2013
The Bolivarian Revolution led by its eternal President Hugo Chávez has its essence in the formation of the socialism that is a process where the values and the beings' human attitudes the development of the society.
Marleni Coromoto López Sánchez   +1 more
doaj  

Knowledge Collaboration: Working with Data and Web Specialists [PDF]

open access: yes, 2015
When resources are finite, people strive to manage resources jointly (if they do not rudely take possession of them). Organizing helps achieve—and even amplify—common purpose but often succumbs in time to organizational silos, teaming for the sake of ...
Serrat, Olivier
core   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

Optimizing human resources competence in the era of digital transformation as a strategic framework for crime prevention and handling

open access: yesJurnal Inovasi Ilmu Sosial dan Politik
The fluctuating crime rate in Gorontalo City necessitates adaptive and responsive police institutions. Strengthening human resources (HR) at the Gorontalo City Resort Police (Polresta) is essential, as personnel play a key role in maintaining public ...
Saadia Alamri   +2 more
doaj   +1 more source

Performance Management and Work Performance Appraisal [PDF]

open access: yesSocietas et Iurisprudentia, 2014
Human resources management has gone through many changes in the past twenty to thirty years and therefore, it is necessary to consider it from the historical point of view.
Iveta Posoldová
doaj  

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