Results 61 to 70 of about 133,164 (249)

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

Respiratory syncytial virus glycoproteins uptake occurs through clathrin-mediated endocytosis in a human epithelial cell line

Virology Journal, 2008
Cell-surface viral proteins most frequently enter the cell through clathrin or caveolae endocytosis. Respiratory syncytial virus antigen internalization by immune cells is via caveolin, however, uptake of paramyxovirus cell membrane proteins by non ...
Gómez-García Beatriz, Sánchez-Hernández Carla, Gutiérrez-Ortega Abel   +2 more
doaj   +1 more source

Mitoxantrone Shows In Vitro, but Not In Vivo Antiviral Activity against Human Respiratory Syncytial Virus

Biomedicines, 2021
Human respiratory syncytial virus (HRSV) is the most common cause of severe respiratory infections in infants and young children, often leading to hospitalization.
Patricia G. de la Sota, Elena Lorente, Laura Notario, Carmen Mir, Oscar Zaragoza, Daniel López   +5 more
doaj   +1 more source

Occurrence of human respiratory syncytial virus in summer in Japan [PDF]

Epidemiology and Infection, 2016
SUMMARY In temperate zones, human respiratory syncytial virus (HRSV) outbreaks typically occur in cold weather, i.e. in late autumn and winter. However, recent outbreaks in Japan have tended to start during summer and autumn. This study examined associations of meteorological conditions with the numbers of HRSV cases reported in ...
Y, Shobugawa, T, Takeuchi, A, Hibino, M R, Hassan, R, Yagami, H, Kondo, T, Odagiri, R, Saito   +7 more
openaire   +2 more sources

Spray‐Dried mRNA‐LNP Powder Enabling Multi‐Route Delivery With 3‐Year Refrigerated Stability

Advanced Science, EarlyView.
Spray‐dried mRNA‐LNP powder with trehalose matrix enables reconstitution for parenteral delivery or direct administration via pulmonary and sublingual routes, maintaining protein expression comparable to liquid controls. The thermostable powder preserves colloidal stability, mRNA integrity, and biological activity for over 3 years at 2°C–8°C, while ...
Ashish Sarode, Priyal Patel, Frank DeRosa, Shrirang Karve, Regis Gervier   +4 more
wiley   +1 more source

Heme Oxygenase-1 Modulates Human Respiratory Syncytial Virus Replication and Lung Pathogenesis during Infection

Journal of Immunology, 2017
Human respiratory syncytial virus (hRSV) is the leading cause of severe lower respiratory tract infections in children. The development of novel prophylactic and therapeutic antiviral drugs against hRSV is imperative to control the burden of disease in ...
Janyra A. Espinoza, Miguel A. León, P. Céspedes, Roberto S. Gómez, Gisela Canedo-Marroquín, S. Riquelme, Francisco J. Salazar-Echegarai, Phillipe Blancou, T. Simon, I. Anegon, Margarita K. Lay, P. González, C. Riedel, S. Bueno, A. Kalergis   +14 more
semanticscholar   +1 more source

Virus isolation and genotype identification of human respiratory syncytial virus in Guizhou Province, China

Brazilian Journal of Infectious Diseases, 2019
To investigate the genetic variation and molecular epidemiology characteristics of Human Respiratory Syncytial Virus (HRSV) in Guizhou Province, nasopharyngeal aspirates were collected from patients with acute respiratory infection (ARI) in Guizhou ...
Ting Zhao, Zhixu Ye, Binlin Wang, Yuxia Cui, Yingjie Nie, Bin Yang, Kun Chen, Hua Zhang, Fangfang Hu, Fuxun Yu   +9 more
doaj   +1 more source

Microfiltration (MF) and Ultrafiltration (UF) for Sewage and Surface Water Concentration for SARS‐CoV‐2 and Other Enveloped Viruses' Detection in Wastewater‐Based Epidemiology (WBE)

Biotechnology and Bioengineering, EarlyView.
ABSTRACT This study objective was to evaluate hollow fiber membranes for concentration of enveloped enteric viruses in sewage and surface water samples. Microfiltration (MF, 0.2 µm nominal pore size) and ultrafiltration (UF, 100 kDa molecular weight cut‐off) hollow fiber membranes were compared for the concentration of the bovine respiratory syncytial ...
Rodrigo Almeria Ragio, Rodrigo de Freitas Bueno, Roseli Frederigi Benassi, Eduardo Lucas Subtil   +3 more
wiley   +1 more source

Virucidal Activity of the Drug «Thymogen®», a Nasal Dosed Spray, Against Human Respiratory Viruses In Vitro

Антибиотики и Химиотерапия
Background. Respiratory syncytial virus (RSV) and parainfluenza virus together account for up to 40% of the pathogens causing acute respiratory infections in children and adults.
V. S. Smirnov, V. V. Zarubaev, T. A. Kudryavtseva, I. L. Esaulkova, A. S. Volobueva, V. A. Zaplutanov, S. V. Petlenko   +6 more
doaj   +1 more source

Prevalence of human respiratory syncytial virus infection in people with acute respiratory tract infections in Africa: A systematic review and meta‐analysis

Influenza and Other Respiratory Viruses, 2018
The epidemiology of human respiratory syncytial virus (HRSV) infection has not yet been systematically investigated in Africa. This systematic review and meta‐analysis are to estimate the prevalence of HRSV infections in people with acute respiratory ...
S. Kenmoe, J. Bigna, E. Well, F. B. N. Simo, V. Penlap, A. Vabret, R. Njouom   +6 more
semanticscholar   +1 more source