Results 51 to 60 of about 3,768,967 (359)

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

open access: yesFEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi   +5 more
wiley   +1 more source

Case report: change of dominant strain during dual SARS-CoV-2 infection

open access: yesBMC Infectious Diseases, 2021
Background The dual infection with SARS-CoV-2 is poorly described and is currently under discussion. We present a study of two strains of SARS-CoV-2 detected in the same patient during the same disease presentation.
Andrei E. Samoilov   +10 more
doaj   +1 more source

A conversation on race (part 1): ‘the geographies of racism’ [PDF]

open access: yes, 2016
The following podcast episodes are the first in a three-week series on the LSE Human Rights Blog entitled ‘A Conversation on Race’
Human Rights, LSE
core  

A realistic utopia? Critical analyses of The Human Rights State in theory and deployment: Guest editors’ introduction [PDF]

open access: yes, 2017
We introduce this special issue on Benjamin Gregg’s recent theory of a human rights state by contextualising it within current human rights scholarship and explicating its core claims, before we provide an overview of the eight contributions.
Gregg, Benjamin, Wolfsteller, Rene
core   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Model Kontrol Keimigrasian dalam Mencegah Tindak Pidana Terorisme di Indonesia

open access: yesLentera Hukum, 2019
This article attempts to elaborate an immigration control model that is capable in preventing terrorist activities in Indonesia. By observing several terrorism case-laws, this study draws a nexus between terrorism and several aspects within immigration ...
Harison Citrawan, Sabrina Nadilla
doaj   +1 more source

Private Governance of Freedom of Expression on Social Media Platforms: EU content regulation through the lens of human rights standards

open access: yesNordicom Review, 2020
For years, social media platforms have been perceived as a democratic gain, facilitating freedom of expression, easy access to a variety of information, and new means of public participation.
Jørgensen Rikke Frank, Zuleta Lumi
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Migrant Rights are Human Rights [PDF]

open access: yes, 2009
Although it is the case that a rights discourse has become part of everyday language, the discourse remains relatively weak when it comes to migrant workers in Canada and around the world. Most certainly, the rights discourse has not been translated into
Hennebry, Jenna
core   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

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