Results 91 to 100 of about 1,593,200 (308)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Protecting and Promoting the Human Right to Respect for Family Life: Treaty-Based Reform and Domestic Advocacy [PDF]
, 2010 This article examines the right to respect for family life in international law, focusing on its underlying principles and explicit protections. The article identifies these legal norms so that drafters of international treaties, specifically the ...
Mrazik, Ryan, Schoenholtz, Andrew I.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Universality Of Human Rights And Thedeath Penalty-The Approach Of The Human Rights Committee [PDF]
, 1997 The application of the death penalty has occupied a number of United Nations human rights treaty bodies, and in particular the Human Rights Committee established under article 28 of the International Covenant on Civil and Political Rights (hereinafter ...
Schmidt, Markus G.
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Walking to the Altar? Equal Marriage in International Human Rights Law
Iuris Dictio, 2018 This text states that, in these last two decades, International Human Rights Law has been a brake for the recognition of equal marriage at the supranational level.
Carlos J. Zelada
doaj +1 more source
TOWARDS A COMPASSIONATE AND COST-EFFECTIVE DRUG POLICY: A FORUM ON THE IMPACT OF DRUG POLICY ON THE JUSTICE SYSTEM AND HUMAN RIGHTS [PDF]
, 1997 This is a transcript from the the first of three panels on drug policy and the impact of drug policy on the justice system and human rights. Don Johnson of the New York Society for Ethical Culture and Tom Haines the Chairman of the Executive Committee ...
core +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Education for human rights: Opportunities and challenges arising from Australian curriculum reform [PDF]
, 2016 © Australian Curriculum Studies Association Incorporated 2016. This paper examines the place of human rights education in Australian schools in the light of the National Curriculum’s implementation and unprecedented educational and social/geopolitical ...
Buchanan, J, Burridge, N
core
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source