Results 61 to 70 of about 3,723,142 (300)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Towards cooperative management of fatigue and vigilance in railway operations [PDF]
ITM Web of ConferencesProfessional drivers face fatigue and decrease of vigilance over the long driving sessions paving their everyday life. This naturally occurring phenomenon is acknowledged and preventive measures, adapted to the vehicles and missions, are deployed around ...
Berdal Quentin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Management of threats and errors in normal operations of assistant controllers : a thesis presented in partial fulfilment of the requirements for the degree of Master in Aviation at Massey University [PDF]
, 2007 "To err is indeed human, so to err is normal" Human errors are usually pronounced in accident or incident reports. Seldom does one pay enough attention to these errors during daily normal operations as these either go unnoticed or unreported for ...
Yeung, Timothy Kwan Chi
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Human safety in the lunar environment [PDF]
Any attempt to establish a continuously staffed base or permanent settlement on the Moon must safely meet the challenges posed by the Moon's surface environment. This environment is drastically different from the Earth's, and radiation and meteoroids are
Lewis, Robert H.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Motion Prediction With Gaussian Processes for Safe Human–Robot Interaction in Virtual Environments
IEEE AccessHumans use collaborative robots as tools for accomplishing various tasks. The interaction between humans and robots happens in tight shared workspaces.
Stanley Mugisha +4 more
doaj +1 more source
Miniature piezoelectric triaxial accelerometer measures cranial accelerations [PDF]
, 1966 Tiny triaxial accelerometer whose sensing elements are piezoelectric ceramic beams measures human cranial accelerations when a subject is exposed to a centrifuge or other simulators of g environments.
Deboo, G. J., Rogallo, V. L.
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source