Results 41 to 50 of about 1,366,283 (308)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Study to evaluate the safety and tolerability of Streptococcus salivarius eK12, a genetically modified strain derived from the oral probiotic S. salivarius K12: Results from a randomized, double-blind, placebo-controlled, parallel-group clinical trial

Frontiers in Nutrition
In recent years, genetically engineered probiotics have gained increasing scientific interest owing to their potential applications in human health and nutrition.
Francesco Di Pierro, Francesco Di Pierro, Francesco Di Pierro, Ali Akbar Bugti, Aasiya Bano, Mehtap Kara, Ikram Ujjan, Nasreen Mumtaz, Yasmeen Gull, Massimiliano Cazzaniga, Alexander Bertuccioli, Maria Laura Tanda, Nicola Zerbinati, Sumbal Hameed, Amjad Khan   +14 more
doaj   +1 more source

Metabolism-Relevant Molecular Classification Identifies Tumor Immune Microenvironment Characterization and Immunotherapeutic Effect in Cervical Cancer

Frontiers in Molecular Biosciences, 2021
Cervical cancer (CESC) is a gynecologic malignant tumor associated with high incidence and mortality rates because of its distinctive management complexity.
Luyi Li, Luyi Li, Hui Gao, Hui Gao, Danhan Wang, Hao Jiang, Hongzhu Wang, Jiajian Yu, Xin Jiang, Changjiang Huang   +9 more
doaj   +1 more source

Human Safety “In The Pocket” of National Safety

Academic Journal of Interdisciplinary Studies, 2015
In everyday life, in real life, tangible public when looking at human security threats to the public look really "human security" at the national level. Often there is no need to make major survey on human security, because in many urban centres and not only the index of human security perspective can become a point of reference for policy as well as ...
Zaho Golemi, Julian Çota
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Patterns of Human Injuries and Fatalities in Fire Incidents in Serbia: A Comprehensive Statistical and Data Mining Analysis

Fire
This manuscript is a continuation of the research published in Fire 2025, 8(8), 302, i.e., it deals with the examination of the cause-and-effect relationships of fires in the Republic of Serbia from the aspect of human safety.
Nikola Mitrović, Vladica Stojanović, Mihailo Jovanović, Željko Grujčić, Dragan Mladjan   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Development of a partially supervised Markov decision-making model for a 3-link collaborative robot-manipulator

Радіоелектронні і комп'ютерні системи
The subject are mathematical models of decision-making under uncertainty in a production environment with human presence. The research objectives: is to form a safe and effective policy for controlling the motion of a three-link collaborative robot ...
Vladyslav Yevsieiev, Dmytro Gurin, Sergii Kulish, Yuliia Voloshyn   +3 more
doaj   +1 more source

Refining the mandibular osteoradionecrosis rat model by in vivo longitudinal µCT analysis

Scientific Reports, 2021
Osteoradionecrosis (ORN) is one of the most feared side effects of radiotherapy following cancers of the upper aero-digestive tract and leading to severe functional defects in patients. Today, our lack of knowledge about the physiopathology restricts the
Morgane Dos Santos, Christelle Demarquay, Louis Ermeneux, Fazia Aberkane, Pauline Bléry, Pierre Weiss, Fabien Milliat, Noëlle Mathieu   +7 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source