Results 61 to 70 of about 1,366,283 (308)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
, 2023 The ISO 26262: Functional Safety – Road Vehicles Standard has been the de-facto automotive functional safety standard since it was first released in 2011.
Debouk, Rami, Rami Debouk
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Towards cooperative management of fatigue and vigilance in railway operations [PDF]
ITM Web of ConferencesProfessional drivers face fatigue and decrease of vigilance over the long driving sessions paving their everyday life. This naturally occurring phenomenon is acknowledged and preventive measures, adapted to the vehicles and missions, are deployed around ...
Berdal Quentin +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
System Safety in Healthcare: Electronic Health Records: Dangers for Patient Safety
, 2015 Electronic health records (EHR) are critical to precision medicine. They provide greater patient access to medical history data and are available quickly. But there are many inherent risks in using these records.
Escano, Maria, Raheja, Dev
core +1 more source
The Railroads and Human Safety [PDF]
Journal of the American Medical Association, 1911 To the Editor: —InThe Journal, April 15, 1911, p. 1113, after citing the list of accidents shown by the accident bulletin of the Interstate Commerce Commission for July, August and September, 1910, you refer to "the deliberate, cynical disregard of human safety which foreign observers are prone to consider an American characteristic," and say: "When ...
openaire +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source