Results 111 to 120 of about 9,264,964 (263)

Effect of urea on warfarin-human serum albumin complex: fluorscence study / Nasim Sakhaei [PDF]

, 2011
In order to evaluate the change in the drug binding ability of human serum albumin (HSA) with the alteration in its native conformation, effect of urea was investigated on the tertiary structure of HSA as well as on its interaction with warfarin, an ...
Sakhaei, Nasim
core  

In vitro effect of the presence of human albumin or human serum on the bactericidal activity of daptomycin against strains with the main resistance phenotypes in Gram-positives

, 2007
Objectives: Bactericidal activity depends on antibiotic-bacteria couples, resistance phenotype and theoretically on protein binding. This work explores the influence of protein binding on the bactericidal activity of two antibiotics, daptomycin versus ...
Giménez, María José, Alou Cervera, Luis, Vallejo, Paloma, Torrico, Martha, Prieto Prieto, José, Aguilar, Lorenzo, González Hidalgo, Natalia, Cafini, Fabio, Sevillano Fernández, David   +8 more
core   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

4-Hydroxycoumarin Derivative: N-(diphenylmethyl)-2-[(2-oxo-2H-chromen-4-yl)oxy]acetamide Interaction with Human Serum Albumin

Journal of Spectroscopy, 2018
In this study, the interaction between the coumarin derivative: N-(diphenylmethyl)-2-[(2-oxo-2H-chromen-4-yl)oxy]acetamide, biologically active drug, and human serum albumin (HSA) was investigated by using various optical spectroscopy techniques along ...
Shanmugavel Chinnathambi, Subramani Karthikeyan, Mangaiyarkarsi Rajendiran, Kanniyappan Udayakumar, Arunkumar Manoharan, Saravanan Kandasamy, Nobutaka Hanagata   +6 more
doaj   +1 more source

Bitmap of human serum albumin with lysine residues highlighted

, 2015
Bitmap of human serum albumin (PDB ID: 1AO6) rendered in VMD where the backbone is cyan3 and all lysine residues are shown in red.
Caitlyn A. Grypma de Jong (751898), Matthew S. MacLennan (666763)   +1 more
core   +1 more source

Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou, Susana Dominguez‐Penuela, David Acero‐Garces, Georgios Gakis, Matthew D. Smith, Yasmin Resto, Maria Reyes‐Mantilla, Haiwen Chen, Isabella Hernandez, Yana Said, Andrea Salazar‐Camelo, Christina Huynh, Alessia Tassoni, Ted Yednock, Rick Artis, Yaisa Andrews‐Zwilling, Scott D. Newsome, Shiv Saidha, Pavan Bhargava, Ellen M. Mowry, Kathryn C. Fitzgerald, Peter A. Calabresi, Carlos A. Pardo, Elias S. Sotirchos   +23 more
wiley   +1 more source

Recombinant production of interleukin-1 receptor antagonist in fusion to albumin binding domain with potential affinity to human serum albumin

Research in Pharmaceutical Sciences
Background and purpose: Anakinra must be injected daily due to its short half-life and this leads to lower patient compliance. Therefore, the aim of this study was to produce an interleukin-1 receptor antagonist (IL-1Ra) with albumin binding domain (ABD)
Fatemeh Shafiee, Ali Yazdani
doaj   +1 more source

Morphological changes in human serum albumin in the presence of cationic amphiphilic drugs

, 2018
Binding of cationic amphiphilic drugs results in unfolding of human serum albumin.
Kabir-ud-Din Kabir-ud-Din, S. Haider, Z. Yaseen, V. K. Aswal, X. Zhou   +4 more
core   +1 more source

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks, Mujeeb Shittu, Anna Wolska, Diala Ghazal, Bianca Weinstock‐Guttman, Alexander Burnham, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +8 more
wiley   +1 more source

Study of interaction between nicotinamide and human serum albumin using spectroscopic techniques and molecular docking simulation simulation

یافته‌های نوین در علوم زیستی, 2022
Human serum albumin is one of the most important blood proteins that has the ability to bind a wide range of compounds and different drugs. Hence, knowing how drugs bind to albumin is crucial to understand their pharmacokinetics and pharmacodynamic ...
Golnaz Parvizi Fard, Lale Solouki, Mostafa Zakariazadeh, Hossein Haghaei, Somaieh Soltani   +4 more
doaj