Results 51 to 60 of about 426,418 (303)

Breaking new ground in mapping human settlements from space -The Global Urban Footprint-

, 2017
Today 7.2 billion people inhabit the Earth and by 2050 this number will have risen to around nine billion, of which about 70 percent will be living in cities.
Achim Roth, Andreas Hirner, Ban, Ban, Batty, Birch, Chang, Chen, Cieslewicz, Clauset, Daily, Dye, Emanuele Strano, Esch, Esch, Esch, Esch, Esch, Gessner, Grimm, Johnson, Julian Zeidler, Kaufmann, Kennelly, Klotz, Krieger, Manfred Keil, Mattia Marconcini, Miyazaki, Moore, Potere, Potere, Schneider, Seto, Stefan Dech, Thomas Esch, Tilman, Werninghaus, Wieke Heldens, Wieland, Zhou, Zhou, Zipf   +42 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

BresNet: Applying Residual Learning in Backpropagation Neural Networks to Predict Ground Surface Concentration of Primary Air Pollutants

Remote Sensing
Monitoring air pollution is important for human health and the environment. Previous studies on the prediction of air pollutants from satellite images have employed machine learning, yet there are few enhancements to the constructure of model.
Zekai Shi, Meng Zhang, Mei Han, Yaowei Zhang, Guodong Ma, Haoyuan Ren   +5 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Utilization of Thermal-Activated Coal Gangue to Enhance the Properties of Sandy Soil Composites

Applied Sciences
To effectively solve the problem of land sanding and improve the water- and element-retaining properties of sandy soil, a thermal-activated coal gangue (TACG) was used as an ameliorating material to prepare a composite soil mixed with sandy soil to ...
Wangtao Fan, Ruofan Liu, Runxia Zhang, Xiaoguang Chen, Jin Li, Aochen Zhang, Jing Qian, Zhaolin Gu, Jianyun Wang   +8 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Research on Optimization Design Strategies for Natural Ventilation in Living Units of Institutional Elderly Care Facilities Based on Computational Fluid Dynamics Simulation

Buildings
As China transitions into a deeply aging society, the elderly population’s growth has driven a rapid increase in elderly care institutions and facilities during the “13th Five-Year Plan” period, rising by over 235% compared to the “12th Five-Year Plan ...
Tianye Liu, Jingxian Wang, Dian Zhou, Xiangzhao Meng, Xilian Luo, Yupeng Wang   +5 more
doaj   +1 more source

Las villas de la frontera granadina y los asentamientos fortificados de época medieval [PDF]

, 1999
This article is about the analisis of the littles walled settlements of medieval period called villas , half way between rural and urban settlements, mainly about the ones situated on the frontier lands of the Granada kingdom and Castilla.
Malpica Cuello, Antonio
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source