Results 61 to 70 of about 426,418 (303)

Enabling communities and markets : meanings, relationships and options in settlement improvement [PDF]

open access: yes
empowerment;poverty alleviation;market;UNCHS;community development;human ...
Helmsing, A.H.J., Wils, F.C.M.
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Location and welfare in cities: impacts of policy interventions on the urban poor [PDF]

open access: yes
Informal settlements are an integral part of the urban landscape in developing countries. These settlements are widely distributed within cities, including central business centers and peripheral areas with environment hazards.
Kapoor, Mudit   +3 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Biochar-Based Remediation of Heavy Metal-Contaminated Soils: Mechanisms, Synergies, and Sustainable Prospects

open access: yesNanomaterials
This study systematically explores the mechanisms and application potential of biochar in remediating heavy metal-contaminated soils. Particular emphasis is placed on the role of raw materials and pyrolysis conditions in modulating key physicochemical ...
Yuxin Wei   +4 more
doaj   +1 more source

WATER, SANITATION AND HUMAN DEVELOPMENT IN URBAN FRINGE SETTLEMENTS IN NIGERIA [PDF]

open access: yes
The importance of water and sanitation facilities has been reflected in the measurement of human development and in their inclusion in Millennium Development Goals (MDGs).
Yekeen A. SANUSI
core  

1982: The Human Settlements and Services Area [PDF]

open access: yes, 1983
This status report is the last of a series initiated in January 1979 to review work of the Human Settlements and Services Area at IIASA for the Area's Advisory Committee.
Rogers, A.
core  

Gatherings of mobility and immobility: itinerant “criminal tribes” and their containment by the Salvation Army in colonial South India [PDF]

open access: yes, 2014
In retelling the history of “criminal tribe” settlements managed by the Salvation Army in Madras Presidency (colonial India) from 1911, I argue that neither the mobility–immobility relationship nor the compositional heterogeneity of (im)mobility ...
Arora, Saurabh
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

A Frontier Model for Landscape Ecology: The Tapir in Honduras [PDF]

open access: yes
We borrow a frontier specification from the econometrics literature to make inferences about the tolerance of the tapir to human settlements. We estimate the width of an invisible band surrounding human settlements which would act as a frontier or ...
Eduardo Ley, Kevin Flesher
core  

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