Results 61 to 70 of about 427,819 (300)

Research on Optimization Design Strategies for Natural Ventilation in Living Units of Institutional Elderly Care Facilities Based on Computational Fluid Dynamics Simulation

Buildings
As China transitions into a deeply aging society, the elderly population’s growth has driven a rapid increase in elderly care institutions and facilities during the “13th Five-Year Plan” period, rising by over 235% compared to the “12th Five-Year Plan ...
Tianye Liu, Jingxian Wang, Dian Zhou, Xiangzhao Meng, Xilian Luo, Yupeng Wang   +5 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Location and welfare in cities: impacts of policy interventions on the urban poor [PDF]

Informal settlements are an integral part of the urban landscape in developing countries. These settlements are widely distributed within cities, including central business centers and peripheral areas with environment hazards.
Kapoor, Mudit, Lall, Somik V., Lundberg, Mattias K. A., Shalizi, Zmarak   +3 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Biochar-Based Remediation of Heavy Metal-Contaminated Soils: Mechanisms, Synergies, and Sustainable Prospects

Nanomaterials
This study systematically explores the mechanisms and application potential of biochar in remediating heavy metal-contaminated soils. Particular emphasis is placed on the role of raw materials and pyrolysis conditions in modulating key physicochemical ...
Yuxin Wei, Jingjing Ma, Kuankuan Liu, Shuai Zhang, Junqi Wang   +4 more
doaj   +1 more source

A Frontier Model for Landscape Ecology: The Tapir in Honduras [PDF]

We borrow a frontier specification from the econometrics literature to make inferences about the tolerance of the tapir to human settlements. We estimate the width of an invisible band surrounding human settlements which would act as a frontier or ...
Eduardo Ley, Kevin Flesher
core  

1982: The Human Settlements and Services Area [PDF]

, 1983
This status report is the last of a series initiated in January 1979 to review work of the Human Settlements and Services Area at IIASA for the Area's Advisory Committee.
Rogers, A.
core  

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

WATER, SANITATION AND HUMAN DEVELOPMENT IN URBAN FRINGE SETTLEMENTS IN NIGERIA [PDF]

The importance of water and sanitation facilities has been reflected in the measurement of human development and in their inclusion in Millennium Development Goals (MDGs).
Yekeen A. SANUSI
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source