Results 1 to 10 of about 976,498 (200)

Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering [PDF]

Cell Reports, 2018
Summary: Generating human skeletal muscle models is instrumental for investigating muscle pathology and therapy. Here, we report the generation of three-dimensional (3D) artificial skeletal muscle tissue from human pluripotent stem cells, including ...
Sara Martina Maffioletti, Shilpita Sarcar, Alexander B.H. Henderson, Ingra Mannhardt, Luca Pinton, Louise Anne Moyle, Heather Steele-Stallard, Ornella Cappellari, Kim E. Wells, Giulia Ferrari, Jamie S. Mitchell, Giulia E. Tyzack, Vassilios N. Kotiadis, Moustafa Khedr, Martina Ragazzi, Weixin Wang, Michael R. Duchen, Rickie Patani, Peter S. Zammit, Dominic J. Wells, Thomas Eschenhagen, Francesco Saverio Tedesco   +21 more
doaj   +3 more sources

Immunohistochemical Identification of Human Skeletal Muscle Macrophages

Bio-Protocol, 2018
Macrophages have well-characterized roles in skeletal muscle repair and regeneration. Relatively little is known regarding the role of resident macrophages in skeletal muscle homeostasis, extracellular matrix remodeling, growth, metabolism and adaptation
Kate Kosmac, Bailey Peck, R. Walton, Jyothi Mula, Philip Kern, Marcas Bamman, Richard Dennis, Cale Jacobs, Christian Lattermann, Darren Johnson, Charlotte Peterson   +10 more
doaj   +2 more sources

Human skeletal muscle aging atlas. [PDF]

Nat Aging
Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with substantial implications for global health. Here we profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human ...
Kedlian VR, Wang Y, Liu T, Chen X, Bolt L, Tudor C, Shen Z, Fasouli ES, Prigmore E, Kleshchevnikov V, Pett JP, Li T, Lawrence JEG, Perera S, Prete M, Huang N, Guo Q, Zeng X, Yang L, Polański K, Chipampe NJ, Dabrowska M, Li X, Bayraktar OA, Patel M, Kumasaka N, Mahbubani KT, Xiang AP, Meyer KB, Saeb-Parsy K, Teichmann SA, Zhang H.   +31 more
europepmc   +2 more sources

Phenotypic features of cancer cachexia‐related loss of skeletal muscle mass and function: lessons from human and animal studies

Journal of Cachexia, Sarcopenia and Muscle, 2021
Cancer cachexia is a complex multi‐organ catabolic syndrome that reduces mobility, increases fatigue, decreases the efficiency of therapeutic strategies, diminishes the quality of life, and increases the mortality of cancer patients. This review provides
Agnès Martin, Damien Freyssenet
doaj   +2 more sources

Complementing muscle regeneration—fibro-adipogenic progenitor and macrophage-mediated repair of elderly human skeletal muscle [PDF]

Nature Communications
The capacity to regenerate skeletal muscle after injury requires a complex and well-coordinated cellular response, which is challenged in aged skeletal muscle.
Jonas Brorson, Lin Lin, Jakob Wang, Amanda Bæk, Tine Borum Billeskov, Frederik Forsberg Thybo, Jesper Just, János Haskó, Christen Ravn, Rehne L. Hansen, Mats Bue, Jens Otto Lunde Jørgensen, Yonglun Luo, Niels Jessen, Jean Farup   +14 more
doaj   +2 more sources

Zinc stimulates glucose oxidation and glycemic control by modulating the insulin signaling pathway in human and mouse skeletal muscle cell lines. [PDF]

PLoS ONE, 2018
Zinc is a metal ion that is an essential cell signaling molecule. Highlighting this, zinc is an insulin mimetic, activating cellular pathways that regulate cellular homeostasis and physiological responses.
Shaghayegh Norouzi, John Adulcikas, Sukhwinder Singh Sohal, Stephen Myers   +3 more
doaj   +2 more sources

The Human Skeletal Muscle Proteome Project:a reappraisal of the current literature [PDF]

Journal of Cachexia, Sarcopenia and Muscle, 2017
Skeletal muscle is a large organ that accounts for up to half the total mass of the human body. A progressive decline in muscle mass and strength occurs with ageing and in some individuals configures the syndrome of 'sarcopenia', a condition that impairs
Aebersold, Akhmedov, Anon, Anton, Baraibar, Berger, Bergstrom, Brinkmeier, Brocca, Burniston, Capitanio, Cesari, Choi, Colberg, Conti, Dam, De Palma, Deshmukh, Egan, Egan, Egerman, Elf, Evans, Feldkirchner, Fernandez-Elias, Gelfi, Gelfi, Gelfi, Gelfi, Giebelstein, Giebelstein, Gillet, Gondin, Gonzalez-Freire, GTEx Consortium. Human genomics, Haehling, Hittel, Hody, Hoedt, Hoffman, Holloway, Hoppeler, Hussey, Hwang, Hwang, Højlund, Højlund, Højlund, Janssen, Jensen, Jensen, Kalyani, Kalyani, Kley, Lane, LeBlanc, Lindskog, Lowell, Lundby, Lundby, Ma, Maerkens, Mann, Martiny, Mason, McLean, Megger, Meng, Michalski, Michalski, Miljkovic, Mora-Rodriguez, Moriggi, Morton, Murgia, Murray, Narumi, Ohlendieck, Ohlendieck, Ohlendieck, Parker, Petersen, Pontén, Poppe, Primmer, Savitski, Schiaffino, Schiaffino, Sela, Shi, Sprung, Staunton, Su, Sun, The Gene Ontology Consortium, Theron, Tyanova, Uhlén, Velders, Viganò, Wijers, Wijers, Zhao, Zhao, Zhao   +104 more
core   +2 more sources

Murine and human myogenic cells identified by elevated aldehyde dehydrogenase activity: Implications for muscle regeneration and repair [PDF]

, 2011
Background: Despite the initial promise of myoblast transfer therapy to restore dystrophin in Duchenne muscular dystrophy patients, clinical efficacy has been limited, primarily by poor cell survival post-transplantation. Murine muscle derived stem cells
Bucsek, MJ, Huard, J, Song, M, Thompson, SD, Vella, JB   +4 more
core   +23 more sources

Human Tissue-Engineered Skeletal Muscle: A Tool for Metabolic Research [PDF]

Endocrinology and Metabolism, 2022
Skeletal muscle is now regarded as an endocrine organ based on its secretion of myokines and exerkines, which, in response to metabolic stimuli, regulate the crosstalk between the skeletal muscle and other metabolic organs in terms of systemic energy ...
Ji-Hoon Kim, Seung-Min Yu, Jang Won Son
doaj   +1 more source

Dose-response of acute capsiate supplementation on muscle endurance performance during CrossFit® in trained men: A randomized, crossover and double-blind study

Human Nutrition & Metabolism, 2023
Objectives: This study aimed to verify the acute effect of Capsiate (CAP) on muscle endurance resistance training during CrossFit® and to compare the effects of two acute doses of CAP supplementation (12 vs.
Marcelo da Silva Mesquita Oliveira, Paulo Renan Macêdo, Nathanael Leal Santana, Flávio Antônio de Sousa Nunes, Jason Michael Cholewa, Priscila Almeida Queiroz Rossi, Ahecio Kleber Araújo Brito, Nelo E. Zanchi, Fabrício Eduardo Rossi   +8 more
doaj   +1 more source