Results 31 to 40 of about 976,647 (347)

Human gut microbiome impacts skeletal muscle mass via gut microbial synthesis of the short‐chain fatty acid butyrate among healthy menopausal women

Journal of Cachexia, Sarcopenia and Muscle, 2021
Increasing evidence suggests that human gut microbiome plays an important role in variation of skeletal muscle mass (SMM). However, specific causal mechanistic relationship of human gut microbiome with SMM remains largely unresolved.
Wan-Qiang Lv, Xu Lin, Hui Shen, Hui-Min Liu, Xiang Qiu, Bo-Yang Li, Wen-Di Shen, Changrong Ge, Feng-Ye Lv, Jie Shen, H. Xiao, H. Deng   +11 more
semanticscholar   +1 more source

Cromakalim (BRL 34915) restores in vitro the membrane potential of depolarized human skeletal muscle fibres [PDF]

, 1989
The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as K+ channel openers, on the electrical activity of human skeletal muscle.
Grafe, Peter, Lehmann-Horn, Frank, Spuler, A.   +2 more
core   +1 more source

Flux control of cytochrome c oxidase in human skeletal muscle [PDF]

, 2000
In the present work, by titrating cytochrome c oxidase (COX) with the specific inhibitor KCN, the flux control coefficient and the metabolic reserve capacity of COX have been determined in human saponin-permeabilized muscle fibers. In the presence of the
Attardi, Giuseppe, Elger, Christian E., Kudin, Alexei, Kunz, Wolfram S., Vielhaber, Stefan, Villani, Gaetano   +5 more
core   +1 more source

A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction

eLife, 2019
Two-dimensional (2D) human skeletal muscle fiber cultures are ill-equipped to support the contractile properties of maturing muscle fibers. This limits their application to the study of adult human neuromuscular junction (NMJ) development, a process ...
Mohsen Afshar Bakooshli, E. Lippmann, Ben Mulcahy, Nisha R. Iyer, Christine T. Nguyen, Kayee Tung, B. Stewart, Hubrecht van den Dorpel, Tobias Fuehrmann, M. Shoichet, A. Bigot, E. Pegoraro, Henry Ahn, H. Ginsberg, Mei Zhen, R. Ashton, P. Gilbert   +16 more
semanticscholar   +1 more source

Bioengineered Viral Platform for Intramuscular Passive Vaccine Delivery to Human Skeletal Muscle

Molecular Therapy: Methods & Clinical Development, 2018
Skeletal muscle is ideal for passive vaccine administration as it is easily accessible by intramuscular injection. Recombinant adeno-associated virus (rAAV) vectors are in consideration for passive vaccination clinical trials for HIV and influenza ...
Nicole K. Paulk, Katja Pekrun, Gregory W. Charville, Katie Maguire-Nguyen, Michael N. Wosczyna, Jianpeng Xu, Yue Zhang, Leszek Lisowski, Bryan Yoo, Jose G. Vilches-Moure, Gordon K. Lee, Joseph B. Shrager, Thomas A. Rando, Mark A. Kay   +13 more
doaj   +1 more source

Metformin Increases Protein Phosphatase 2A Activity in Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants

Journal of Diabetes Research, 2021
Context. Skeletal muscle insulin resistance is one of the primary contributors of type 2 diabetes (T2D). Metformin is the first-line drug for the treatment of T2D.
Aktham Mestareehi, Xiangmin Zhang, Berhane Seyoum, Zaher Msallaty, Abdullah Mallisho, Kyle Jon Burghardt, Anjaneyulu Kowluru, Zhengping Yi   +7 more
doaj   +1 more source

Human skeletal muscle nitrate store: influence of dietary nitrate supplementation and exercise

Journal of Physiology, 2019
Nitric oxide (NO), a potent vasodilator and a regulator of many physiological processes, is produced in mammals both enzymatically and by reduction of nitrite and nitrate ions.
Lee J. Wylie, J. W. Park, A. Vanhatalo, Stefan Kadach, Matthew I. Black, Zdravko Stoyanov, A. Schechter, A. Jones, B. Piknova   +8 more
semanticscholar   +1 more source

Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease [PDF]

, 2017
Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system.
Matsakas, Antonios, Sfyri, Peggy
core   +1 more source

Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

eLife, 2019
A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty in older persons, but the molecular mechanisms of such decline are not understood.
C. Ubaida-Mohien, A. Lyashkov, M. Gonzalez-Freire, Ravi Tharakan, M. Shardell, R. Moaddel, R. Semba, C. Chia, M. Gorospe, R. Sen, L. Ferrucci   +10 more
semanticscholar   +1 more source

11 beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle [PDF]

, 2009
OBJECTIVE: Glucocorticoid excess is characterized by increased adiposity, skeletal myopathy, and insulin resistance, but the precise molecular mechanisms are unknown.
Morgan, S. A., Sherlock, M., Gathercole, L.L, Lavery, Gareth G., Lenaghan, C., Bujalska, I.J, Laber, D., Yu, A., Convey, G., Mayers, R., Hegyi, K., Sethi, J. K., Stewart, P M, Smith, D. M., Tomlinson, J W   +14 more
core   +6 more sources