Results 41 to 50 of about 976,647 (347)

Skeletal Muscle Is an Endocrine Organ

Journal of Pharmacological Sciences, 2014
.: Skeletal muscle plays a key role in postural retention as well as locomotion for maintaining the physical activities of human life. Skeletal muscle has a second role as an elaborate energy production and consumption system that influences the whole ...
Kenji Iizuka, Takuji Machida, Masahiko Hirafuji   +2 more
doaj   +1 more source

Human and Rodent Skeletal Muscles Express Angiotensin II Type 1 Receptors

Cells, 2020
Abundant evidence reveals that activation of the renin-angiotensin system promotes skeletal muscle atrophy in several conditions including congestive heart failure, chronic kidney disease, and prolonged mechanical ventilation. However, controversy exists
Rafael Deminice, Hayden Hyatt, Toshinori Yoshihara, Mustafa Ozdemir, Branden Nguyen, Sanford Levine, Scott Powers   +6 more
doaj   +1 more source

Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males [PDF]

, 2014
Vitamin D may be a regulator of skeletal muscle function, although human trials investigating this hypothesis are limited to predominantly elderly populations.
Close, Graeme L, Donovan, Timothy F, Fraser, William D, Impey, Samuel G, Morton, James P, Owens, Daniel J, Tang, Jonathan, Webber, Daniel   +7 more
core   +1 more source

Microstructural analysis of skeletal muscle force generation during aging. [PDF]

, 2020
Human aging results in a progressive decline in the active force generation capability of skeletal muscle. While many factors related to the changes of morphological and structural properties in muscle fibers and the extracellular matrix (ECM) have been ...
Basava, Ramya R, Chen, Jiun-Shyan, He, Qizhi, He, Xiaolong, Hodgson, John, Sinha, Shantanu, Sinha, Usha, Zhang, Yantao   +7 more
core   +1 more source

Sarcopenia, Dynapenia, and the Impact of Advancing Age on Human Skeletal Muscle Size and Strength; a Quantitative Review

Front. Physio., 2012
Changing demographics make it ever more important to understand the modifiable risk factors for disability and loss of independence with advancing age.
W. Kyle Mitchell, John P. Williams, P. Atherton, M. Larvin, J. Lund, M. Narici   +5 more
semanticscholar   +1 more source

Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy [PDF]

, 2013
BACKGROUND: Spinal muscular atrophy (SMA) is a neuromuscular disease resulting from mutations in the survival motor neuron 1 (SMN1) gene. Recent breakthroughs in preclinical research have highlighted several potential novel therapies for SMA, increasing ...
Gillingwater, T. H., Hunter, G., Lamont, D. J., Mutsaers, C. A., Wishart, T. M.   +4 more
core   +3 more sources

Human Skeletal Muscle Possesses an Epigenetic Memory of Hypertrophy

Scientific Reports, 2018
It is unknown if adult human skeletal muscle has an epigenetic memory of earlier encounters with growth. We report, for the first time in humans, genome-wide DNA methylation (850,000 CpGs) and gene expression analysis after muscle hypertrophy (loading ...
Robert A. Seaborne, J. Strauss, M. Cocks, S. Shepherd, T. D. O’Brien, Ken A. van Someren, P. Bell, C. Murgatroyd, J. Morton, C. Stewart, A. Sharples   +10 more
semanticscholar   +1 more source

Modeling the ACVR1R206H mutation in human skeletal muscle stem cells

eLife, 2021
Abnormalities in skeletal muscle repair can lead to poor function and complications such as scarring or heterotopic ossification (HO). Here, we use fibrodysplasia ossificans progressiva (FOP), a disease of progressive HO caused by ACVR1R206H (Activin ...
Emilie Barruet, Steven M Garcia, Jake Wu, Blanca M Morales, Stanley Tamaki, Tania Moody, Jason H Pomerantz, Edward C Hsiao   +7 more
doaj   +1 more source

A 96-well culture platform enables longitudinal analyses of engineered human skeletal muscle microtissue strength

bioRxiv, 2019
Three-dimensional (3D) in vitro models of human skeletal muscle mimic aspects of native tissue structure and function, thereby providing a promising system for disease modeling, drug discovery or pre-clinical validation, and toxicity testing.
Mohammad E. Afshar, Haben Y. Abraha, M. A. Bakooshli, S. Davoudi, Nimalan Thavandiran, Kayee Tung, Henry Ahn, H. Ginsberg, P. Zandstra, P. Gilbert   +9 more
semanticscholar   +1 more source

Neural cell integration into 3D bioprinted skeletal muscle constructs accelerates restoration of muscle function

Nature Communications, 2020
3D bioprinting of skeletal muscle using primary human muscle progenitor cells results in correct muscle architecture, but functional restoration in rodent models is limited. Here the authors include human neural stem cells into bioprinted skeletal muscle
Ji Hyun Kim, Ickhee Kim, Young-Joon Seol, In Kap Ko, James J. Yoo, Anthony Atala, Sang Jin Lee   +6 more
doaj   +1 more source