Results 101 to 110 of about 9,000,670 (290)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Disparities in being able to donate human milk impacts upon maternal wellbeing: Lessons for scaling up milk bank service provision

Maternal and Child Nutrition
Receiving donor human milk for a baby can have a protective effect upon parental wellbeing. A growing body of research also finds that being able to donate milk to a milk bank, particularly after infant loss, can also boost maternal wellbeing through ...
Amy Brown, Catrin Griffiths, Sara Jones, Gillian Weaver, Natalie Shenker   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

‘I Do Often Feel Like We Were Given a Magic Wand’ – Children's and Families’ Experiences of Allied Health Services for Developmental and Disability Needs in Rural and/or Remote South Australia

Health Expectations
Background Children in rural and remote areas are increasingly developmentally vulnerable compared to metropolitan peers. Allied health professionals are positioned to provide services to support children with developmental and disability needs but face ...
Georgia Gosse, Saravana Kumar, Helen Banwell, Joshua Pate   +3 more
doaj   +1 more source

Concentrations of selected human milk components influence the infant oral microbiome to a greater degree than estimated intakes

Frontiers in Cellular and Infection Microbiology
BackgroundHuman milk is characterised by its complex composition, consisting of nutrient and bioactive components that play a crucial role in infant health.
Roaa A. Arishi, Roaa A. Arishi, Roaa A. Arishi, Roaa A. Arishi, Ali S. Cheema, Jacki L. McEachran, Jacki L. McEachran, Jacki L. McEachran, Zoya Gridneva, Zoya Gridneva, Zoya Gridneva, Phil Vlaskovsky, Isabella Norrish, Sabrina H. Bilston-John, Xiaojie Zhou, Ching Tat Lai, Ching Tat Lai, Ching Tat Lai, Matthew S. Payne, Donna T. Geddes, Donna T. Geddes, Donna T. Geddes, Lisa F. Stinson, Lisa F. Stinson, Lisa F. Stinson   +24 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Development of the breastfed infant oral microbiome over the first two years of life in the BLOSOM Cohort

Frontiers in Cellular and Infection Microbiology
BackgroundAcquisition and development of the oral microbiome are dynamic processes that occur over early life. This study aimed to characterize the temporal development of the oral microbiome of predominantly breastfed infants during the first two years ...
Roaa A. Arishi, Roaa A. Arishi, Roaa A. Arishi, Roaa A. Arishi, Ali S. Cheema, Ching T. Lai, Ching T. Lai, Ching T. Lai, Matthew S. Payne, Donna T. Geddes, Donna T. Geddes, Donna T. Geddes, Lisa F. Stinson, Lisa F. Stinson, Lisa F. Stinson   +14 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source