Results 201 to 210 of about 425,761 (264)

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Packed-nanofiber solid phase extraction for daidzein, genistein, glycitein in human urine and their simultaneous detection. [PDF]

RSC Adv
Dai Y, Zhang L, Wang Y, Fu A, Chu L, Zhao L.   +5 more
europepmc   +1 more source

Modeling Catheter‐Associated Bladder Mucosal Adhesion and Microtrauma Using a Human Urothelial Microtissue Model

Advanced NanoBiomed Research, EarlyView.
Intermittent catheter use can damage the urinary tract and predispose to infection. We deployed a complex human urothelial model to investigate. Catheter contact induced compressive and shear stress causing umbrella cell disruption, reduced barrier function, inflammation and increased cell adhesion to the catheter surface.
Nazila V. Jafari, Jennifer L. Rohn
wiley   +1 more source

Human urine-derived stem cells rescue cutaneous manifestation and suppress inflammation and fibrosis <i>in vitro</i> and in a mouse model of recessive dystrophic epidermolysis bullosa. [PDF]

Burns Trauma
Zhou X, Tan J, Song Y, Liu P, Zhang X, Feng X, Xiao Y, Wang Y, Liu G, Zhang W, Zhang Q, Jiang Y, Liu Y, Zhao L, Xie H, Li W.   +15 more
europepmc   +1 more source

A Sensitive SPE-LC-MS/MS Method for Determination of Selected Veterinary Drugs and Other Organic Contaminants in Human Urine: Development, Validation, and Application Study. [PDF]

Int J Mol Sci
Rodzaj W, Wacławik M, Jurewicz J, Wielgomas B.   +3 more
europepmc   +1 more source

Implementation of Sensitive Method for Determination of Benzophenone and Camphor UV Filters in Human Urine. [PDF]

Toxics
Gomersall V, Ciglova K, Pulkrabova J.
europepmc   +1 more source

Protocol for using MYOD1-transduced human urine-derived cells as a predictive platform for exon skipping therapy in Duchenne muscular dystrophy. [PDF]

STAR Protoc
Kunitake K, Ishizuka T, Takeshita E, Komaki H, Aoki Y.   +4 more
europepmc   +1 more source

Endogenous retroviral ERVH48-1 promotes human urine cell reprogramming. [PDF]

Cell Regen
Peng Y, Zhu J, Zhang Q, Zhang R, Wang Z, Ye Z, Ma N, Qin D, Pei D, Li D.   +9 more
europepmc   +1 more source

Exosomes from CD133⁺CD271⁺ human urine-derived stem cells combined with a novel photosensitive hydrogel promote repair after spinal cord injury. [PDF]

J Transl Med
Deng C, Yuan F, Li C, Tong X, Qin Y, Wen H, Qin T, Liu Y, Wu T, Duan C, Xu Y, Cao Y, Lu H, Hu J.   +13 more
europepmc   +1 more source

Cost Minimized Immunoaffinity Purification of EPO and Its Analogs in Doping Control-A Step-by-Step Protocol for Human Urine and Blood. [PDF]

Drug Test Anal
Reichel C, Gmeiner G, Thevis M.
europepmc   +1 more source