Results 91 to 100 of about 75,155 (200)

Evaluation of Four Humanized NOD-Derived Mouse Models for Dengue Virus-2 Infection

Pathogens
Dengue is a significant public health problem with no specific viral treatment. One of the main challenges in studying dengue is the lack of adequate animal models recapitulating human immune responses.
Hernando Gutierrez-Barbosa, Sandra Medina-Moreno, Federico Perdomo-Celis, Harry Davis, Joel V. Chua, Juan C. Zapata   +5 more
doaj   +1 more source

Humanized mouse model reveals T cell ANXA2 as a potential therapeutic target in ischemic stroke

iScience
Summary: Stroke T cell studies in rodents have not been translated to human studies. The mechanism of cellular and molecular T cells changes after stroke remains incompletely understood.
Tianyuan Zhang, Xiaojuan Zheng, Aijun Lu, Shuyuan Li, Keshen Li, Xiaoxiong Huang, Yanfang Liu, Wei Chen, Shengming Huang, Niu He, Chi Kwan Tsang, Hongcheng Mai, Anding Xu, Dan Lu   +13 more
doaj   +1 more source

Dynamics of HBV infection in humanized mice.

(A) and (B) show fits of the mathematical model to the extracellular viral markers in peripheral blood of humanized mice treated with ETV or PEG IFN-α (black: HBcrAg, green: HBV DNA, blue: HBeAg, red: HBsAg).
Lena Allweiss (366520), Yasuhito Tanaka (39138), Naotoshi Nakamura (12083048), Shinji Nakaoka (3326025), Maura Dandri (560334), Kwang Su Kim (1960972), Yasuhisa Fujita (10344689), Koichi Watashi (222543), Hyeongki Park (15990598), Masashi Iwamoto (1399939), Kosaku Kitagawa (9187891), Shingo Iwami (266092), Kazuyuki Aihara (44090), Alan S. Perelson (7832039), Takara Nishiyama (18137383), Sanae Hayashi (18137380)   +15 more
core   +1 more source

A humanized neutralizing antibody protects against human adenovirus type 7 infection in humanized desmoglein-2 and CD46 double-receptor transgenic mice

Virology Journal
Background Human adenovirus type 7 (HAdV7) has become a major public health threat due to its widespread transmission, severe associated pneumonia, and a lack of effective anti-HAdV7 drugs. The aim of the current study is to design a humanized monoclonal
Chengxing Zhou, Xiaohong Liao, Zhichao Zhou, Chuncong Mo, Yujie Yang, Hui Liao, Minglei Liu, Qiong Zhang, Qiuru Li, Xingui Tian, Rong Zhou, Hong Cao   +11 more
doaj   +1 more source

A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice

International audienceImmunoglobulin E (IgE) antibodies play a key role in allergy and its most dangerous and life-threatening manifestation, anaphylaxis.
Apoil, Pol-André, Bonnefoy, Jonathan, Malissen, Bernard, Pecalvel, Cyprien, Jönsson, Friederike, Conde, Eva, Mauré, Emilie, Andrieux, Léna, Bruhns, Pierre, Kamphuis, Jasper, Iannascoli, Bruno, Loste, Alexia, Colaone, Fabien, Breloer, Minka, Godon, Ophélie, Guilleminault, Laurent, Lamanna, Emma, Linnemann, Lara, Leveque, Edouard, Lemdani, Katia, Stackowicz, Julien, Gaudenzio, Nicolas, Backovic, Marija, Serra, Vincent, Reber, Laurent, Fiore, Frédéric, Drouet, Béatrice, Worrall, William, Benmessaoud, Zohra, England, Patrick, Hamdi, Samir, Mougel, Aurélie   +31 more
core   +1 more source

Of Mice and Humans [PDF]

Environmental Health Perspectives, 1997
openaire   +2 more sources

Animal model considerations for chordoma research: reproducing the tumor microenvironment in vivo with humanized mice

Frontiers in Oncology
Animal models have been commonly used in immunotherapy research to study the cell response to external agents and to assess the effectiveness and safety of new therapies.
Beatrice Campilan, Christian Schroeder, Emilija Sagaityte, Jonathan Arditi, Owen P. Leary, Ziya L. Gokaslan, Patricia L. Zadnik Sullivan, Margot Martinez-Moreno   +7 more
doaj   +1 more source

Induction of severe H7N9 infection in humanized mice.

, 2015
Humanized mice were infected with H7N9 virus i.n. at different dose (106, 104, 102 TCID50) in 25μl of saline solution on day 0. The weight change (A) and survival (B) in virus-infected mice (5 mice per group) were monitored and recorded till day 15 post ...
Yinping Liu (399766), Kwok-Hung Chan (156922), Wai-Lan Wu (784684), Zheng Xiang (336195), Jasper Fuk-Woo Chan (580515), Honglin Chen (83242), Kwok-Yung Yuen (2377228), Yu-Lung Lau (202519), Jian Zheng (287758), Lanjuan Li (112956), Ming Liu (105953), Kwok-Tai Lam (430242), Wenwei Tu (399769), Siu-Ying Lau (784685), Kelvin Kai-Wang To (580514)   +14 more
core   +1 more source

Modeling HIV-1 pathogenesis and therapy in humanized mice

, 2019
Human immunodeficiency virus type 1 (HIV-1) is the causative agent of acquired immunodeficiency syndrome (AIDS) and currently, there are no complete cure or effective vaccines available.
凌理軍, Ling, Lijun
core  

Of Mice and Humans

Journal of Science, Humanities and Arts - JOSHA, 2022
openaire   +2 more sources