Results 81 to 90 of about 75,155 (200)
Generating C-peptide Humanized Mice
, 2012 Type 1 diabetes is primarily caused by the loss of insulin producing beta-cells. Future therapies based on transplantation of in vitro generated beta-cells hold great promise for providing a cure.
Nelson, Seana ML
core +1 more source
Improved human hematopoietic reconstitution in HepaRG co-transplanted humanized NSG mice
, 2020 Several humanized mouse models are being used to study human-specific immune responses and diseases. However, the pivotal needs of fetal tissues for the humanized mice model have been huddled because of the demand for ethical and medical approval.
Ryu, Bokyeong +6 more
core +1 more source
Establishment and immune phenotyping of patient-derived glioblastoma models in humanized mice
Frontiers in ImmunologyGlioblastoma (GBM) is the most aggressive and common type of malignant brain tumor diagnosed in adults. Preclinical immunocompetent mouse tumor models generated using mouse tumor cells play a pivotal role in testing the therapeutic efficacy of emerging ...
Longsha Liu +16 more
doaj +1 more source
Interferon-alpha treatment rapidly clears Hepatitis E virus infection in humanized mice
Scientific Reports, 2017 Antiviral treatment options for chronic Hepatitis E Virus (HEV) infections are limited and immunological determinants of viral persistence remain largely unexplored.
Martijn D. B. van de Garde +7 more
doaj +1 more source
Humanized mice for the study of infectious diseases
, 2014 Many of the pathogens that cause human infectious diseases do not infect rodents or other mammalian species. Small animal models that allow studies of the pathogenesis of these agents and evaluation of drug efficacy are critical for identifying ways to ...
Jouvet, Nathalie +3 more
core +1 more source
Human autoimmunity genes in mice
Current Opinion in Immunology, 2000 In the post-genomic era, the expression and investigation of human (auto)immunity genes seems more relevant than ever. The generation of humanized animal models of human diseases will be useful to study the interplay between genetic and non-genetic factors in disease development and may form a basis for the development of new drugs that act more ...
openaire +3 more sources
Animal Models and Experimental MedicineBackground Humanized mouse models are essential for studying the human immune response and antibody development. However, conventional models show limited B cell maturation and antigen‐specific humoral responses.
Dong Hoon Lee +11 more
doaj +1 more source
Humanized Mice as Preclinical Models in Transplantation
, 2016 Animal models have been instrumental in our understanding of the mechanisms of rejection and the testing of novel treatment options in the context of transplantation. We have now entered an exciting era with research on humanized mice driving advances in
Becker, P D +11 more
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CD4(+) cell-dependent granuloma formation in humanized mice infected with mycobacteria
, 2013 We have used humanized mice, in which human immune cells differentiate de novo from transplanted cord blood progenitor cells, to study the human immune responses to infection with Mycobacterium bovis bacillus Calmette-Guerin and Mycobacterium ...
Gavier-Widén, Dolores, +1 more
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Editorial: Development of Humanized Mouse Models for Infectious Diseases and Cancer
Frontiers in Immunology, 2020 Moriya Tsuji, Ramesh Akkina
doaj +1 more source