Results 61 to 70 of about 75,155 (200)
Genetic Variations in Atherosclerosis: "Humans to Mice" and "Mice to Humans"
The FASEB Journal, 2009 The risk of atherosclerosis in humans increases progressively in association with the three common alleles of APOE in the order APOE*2 < APOE*3 < APOE4
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The Fluctuations of Leukocytes and Circulating Cytokines in Septic Humanized Mice Vary With Outcome
Frontiers in Immunology, 2019 Sepsis remains a major challenge in translational research given its heterogeneous pathophysiology and the lack of specific therapeutics. The use of humanized mouse chimeras with transplanted human hematopoietic cells may improve the clinical relevance ...
Tomasz Skirecki +7 more
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Engineering humanized mice for improved hematopoietic reconstitution [PDF]
, 2012 Humanized mice are immunodeficient animals engrafted with human hematopoietic stem cells that give rise to various lineages of human blood cells throughout the life of the mouse.
Chen, Jianzhu +2 more
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Osteoimmunology: from mice to humans [PDF]
bonekey Reports, 2016 The immune system has been recognized as one of the most important regulators of bone turnover and its deregulation is implicated in several bone diseases such as postmenopausal osteoporosis and inflammatory bone loss; recently it has been suggested that the gut microbiota may influence bone turnover by modulation of the immune system. The study of the
Patrizia, D'Amelio, Francesca, Sassi
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Infectious diseases in humanized mice [PDF]
European Journal of Immunology, 2013 Despite many theoretical incompatibilities between mouse and human cells, mice with reconstituted human immune system components contain nearly all human leukocyte populations. Accordingly, several human‐tropic pathogens have been investigated in these in vivo models of the human immune system, including viruses such as human immunodeficiency virus ...
Leung, Carol +8 more
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Humanized mice with ectopic artificial liver tissues
, 2011 “Humanized” mice offer a window into aspects of human physiology that are otherwise inaccessible. The best available methods for liver humanization rely on cell transplantation into immunodeficient mice with liver injury but these methods have not gained
Golub, Todd +11 more
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, 2022 The constitutive androstane receptor (CAR) controls xenobiotic clearance, regulates liver glucose, lipid metabolism, and energy homeostasis. These functions have been mainly discovered using the prototypical mouse-specific CAR ligand TCPOBOP in wild-type
Stahl, Aaron +9 more
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Creation of humanized mice to study human immunity.
, 2008 Humanized mice are a promising translational model for studying human hematopoiesis and immunity. Their utility has been enhanced by the development of new stocks of immunodeficient hosts, most notably mouse strains such as NOD-scid IL2rgamma(null ...
Greiner, D L +8 more
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Sensitization of Mice with Human IgA [PDF]
Nature, 1966 IT is well known that an increased vascular permeability produced by various agents can be visualized by the leakage of intravenously administered dye through the affected vessels. The vascularity and high histamine and serotonin content of mouse ears1 suggested that these organs might be useful in the visualization of in vivo antigen–antibody ...
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Humanized mice succumb to antibody application.
, 2016 Humanized mice were injected i.v. with 20 μg OKT3 or 20 μg TGN1412 per 10 grams body weight. 1 hour before, indicated humanized mice were treated with 10 μg anti-human TNF-α mAb per mouse (C-E). As control, humanized mice were injected with PBS (A-B). (A)
Ulrich Kalinke (41173) +7 more
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