Results 51 to 60 of about 75,155 (200)
Establishment of a humanized ST6GAL1 mouse model for influenza research
Animal Models and Experimental MedicineBackground This study aimed to construct and characterize a humanized influenza mouse model expressing hST6GAL1. Methods Humanized fragments, consisting of the endothelial cell‐specific K18 promoter, human ST6GAL1‐encoding gene, and luciferase gene, were
Lyu Chao +12 more
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A Humanized Mouse Model Generated Using Surplus Neonatal Tissue
Stem Cell Reports, 2018 Summary: Here, we describe the NeoThy humanized mouse model created using non-fetal human tissue sources, cryopreserved neonatal thymus and umbilical cord blood hematopoietic stem cells (HSCs).
Matthew E. Brown +10 more
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, 2012 Allogeneic stem cell transplantation (allo-SCT) has become an important treatment modality for patients with high-risk acute myeloid leukemia (AML) and is also under investigation for soft tissue sarcomas.
Wels, Winfried +35 more
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Studies of retroviral infection in humanized mice [PDF]
, 2015 Many important aspects of human retroviral infections cannot be fully evaluated using only in vitro systems or unmodified animal models. An alternative approach involves the use of humanized mice, which consist of immunodeficient mice that have been ...
Marsden, Matthew D. +5 more
core +1 more source
Human tumors in immunocompetent mice [PDF]
Nature Methods, 2020 A new platform allows researchers to study the tumor microenvironment in fully immunocompetent chimeric mice.
openaire +2 more sources
Plaque Rupture in Humans and Mice [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2007 Despite the many studies of murine atherosclerosis, we do not yet know the relevance of the natural history of this model to the final events precipitated by plaque disruption of human atherosclerotic lesions. The literature has become particularly confused because of the common use of terms such as “instability”, “vulnerable”, “rupture”, or even ...
Schwartz, Stephen M +3 more
openaire +3 more sources
Complete functional rescue of the ABCA1−/− mouse by human BAC transgenesis
Journal of Lipid Research, 2005 Humanized mouse models are useful tools to explore the functional and regulatory differences between human and murine orthologous genes. We have combined a bioinformatics approach and an in vivo approach to assess the functional and regulatory ...
Jonathan M. Coutinho +11 more
doaj +1 more source
mAbs, 2020 A major asset of many monoclonal antibody (mAb)-based biologics is their persistence in circulation. The MHC class I family Fc receptor, FCGRT, is primarily responsible for this extended pharmacokinetic behavior.
Benjamin E. Low +4 more
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PLoS ONE, 2020 Complement is a key component of the innate immune system. Inappropriate complement activation underlies the pathophysiology of a variety of diseases. Complement component 5 (C5) is a validated therapeutic target for complement-mediated diseases, but the
Adrianna Latuszek +27 more
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CYP3A4 and pregnane X receptor humanized mice
, 2007 Marked species differences exist in P450 expression and activities. In order to produce mouse models that can be used to more accurately predict human drug and carcinogen metabolism, P450‐ and xenobiotic receptor humanized mice are being prepared using ...
Gonzalez, Frank J., Frank J. Gonzalez
core +1 more source